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IL6 Antibody (OASA05650)

0.5 mg
$789.00
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Gene Symbol:
Il6
NCBI Gene Id:
16193
Protein Name:
Interleukin-6
Swissprot Id:
P08505
Protein Accession #:
NP_112445.1
Alias Symbols:
Il-6, Il6
Replacement Item:
This antibody may replace item sc-1265 from Santa Cruz Biotechnology.
Description of Target:
RAT ANTI MOUSE INTERLEUKIN-6
Protein Size (# AA):
211
Host:
Rat
Clonality:
Monoclonal
Purification:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Application:
ELISA
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express Il6.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express Il6.
Immunogen:
The immunogen for anti-Il6 antibody: recombinant murine IL-6
Predicted Species Reactivity:
Mouse
Predicted Homology Based on Immunogen Sequence:
Mouse
Product Format:
Purified IgG - liquid
Reconstitution and Storage:
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Datasheets/Manuals:
Printable datasheet for anti-Il6 antibody - OASA05650
Specificity:
Rat anti Mouse Interleukin-6 antibody, clone MP5-20F3 recognizes mouse Interleukin 6 (IL-6). IL-6 is a potent lymphoid cell growth factor which is principally expressed by macrophages and T-cells.
Rat anti Mouse Interleukin-6 antibody, clone MP5-20F3 may be used to neutralize IL-6 bioactivity in a functional assay (Abrams et al. 1992 and Kambayashi et al. 1995).
Clone:
MP5-20F3
Isotype:
IgG1
Application Info:
ELISA : This antibody may be used in combination with clone MP5-32C11 (OASA05651) in sandwich ELISA and ELISPOT assays.
:::
Preservative Stabilisers: 0.09% - Sodium Azide
:::
Approx Protein Conc: IgG concentration 1.0 mg/ml
Buffer Solutions: Phosphate buffered saline pH7.4
Target Reference:
1. Abrams, J.S. et al. (1992) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127: 5-24.
2. Kambayashi, T. et al. (1995) Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF alpha and IL-6 release by endotoxin-stimulated macrophages. J. Immunol. 155: 4909-4916.
3. Vankelecom, H. et al. (1993) Immunocytochemical evidence that S-100- positive cells of the mouse anterior pituitary contain Interleukin-6 immunoreactivity. J. Histochem. Cytochem. 41: 151-156.
4. Skok, J. et al. (1999) Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: A feedback regulation of Th1 development. J. Immunol. 163: 4284-4291.

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