IL4R Protein (OPTA00928)

Catalog No: OPTA00928

Product Info

• Tested Species Reactivity: Human
• Product Format: Lyophilized
• Application: CA
  Bioactivity: The expected ED50 of <= 5.0 ng/ml, corresponding to a specific activity of >= 2 x 105 units/mg, is measured by determining the ability to inhibit the IL-4 dependent proliferation of human TF-1 cells while in the presence of 0.5 ng/ml I
  Endotoxin Level: Endotoxin level is <0.1 ng/ug of protein (<1 EU/ug).
• Reconstitution and Storage: -20C
• Purity: 98%
• Protein Sequence: GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN SYREPFEQH
• Source: HEK293 cells
• Reference:

  Maliszewski CR, Sato TA, Davison B, Jacobs CA, Finkelman FD and Fanslow WC. 1994. Proc Soc Exp Biol Med. 206(3): 233-7.

  Kruse S, Forster J, Kuehr J and Deichmann KA. 1999. Int Immunol. 11(12): 1965-1970.

  Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K and Sugamura K. 1993. Science. 262(5141): 1874-1877.

  Wills-Karp M and Finkelman FD. 2008. Sci Signal. 1(51): pe55.

  Jung T, Schrader N, Hellwig M, Enssle KH and Neumann C. 1999. Int Arch Allergy Immunol. 199(1): 23-30.

Target Info

• Gene Symbol: IL4R
• Gene Full Name: interleukin 4 receptor
• Alias Symbols: CD124, IL4RA, IL-4RA
• NCBI Gene Id: 3566
• Protein Name: interleukin-4 receptor subunit alpha
• Description of Target: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.