Il33 Recombinant Protein (Rat) (OPED00076)

Catalog No: OPED00076

Size:10UG

SDS-PAGE analysis: Lane 1: MW Marker; Lane 2: 1.0μg of purified IL-33 (rat), (recombinant).

Product Info

• Predicted Species Reactivity: Rat|Rattus norvegicus
• Product Format: Lyophilized. Contains PBS.
• Host: E. Coli
• Additional Information: IL-33 is a member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1RL1) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-kappa B and MAPK pathways. The human IL-33 protein is expressed with a prodomain (aa 1-111) which is cleaved by caspase-1 to produce the 18kDa mature protein (112-270).
• Reconstitution and Storage: Reconstitute with 100 ul sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum. Store at -20C
• Purity: >95% (SDS-PAGE)
• Reference: Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation: A.M. Küchler, et al.; Am. J. Pathol. 173, 1229 (2008), Abstract;
  General Literature References
  IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system: S. Sanada, et al.; J. Clin. Invest. 117, 1538 (2007), Abstract; Full Text
  IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005), Abstract;

Target Info

• Gene Symbol: Il33
• Gene Full Name: interleukin 33
• Alias Symbols: IL-33;interleukin-33;RGD1311155.
• NCBI Gene Id: 361749
• Protein Name: Interleukin-33
• Description of Target: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (By similarity).
• Uniprot ID: Q66H70
• Protein Accession #: NP_003325.2
• Nucleotide Accession #: NM_003334.3
• Protein Size (# AA): Recombinant
• Molecular Weight: 16 kDa