Il33 Recombinant Protein (Mouse) (OPED00075)

Catalog No: OPED00075

Size:10 ug

SDS-PAGE analysis: Lane 1: MW Marker; Lane 2: 1.0ug of purified IL-33 (mouse), (recombinant).

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Lyophilized. Contains PBS.
• Host: E. Coli
• Additional Information: IL-33 is a member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1RL1) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-kappa B and MAPK pathways. The mouse IL-33 protein is expressed with a prodomain (aa 1-108) which is cleaved to produce the 18kDa mature protein (109-266). Historical data has shown that IL-33 activates mouse and human ST2-dependent NF-kappa B pathway and induces IL-6 production in P815 mastocytoma cells and in bone marrow derived mast cells.
• Reconstitution and Storage: Reconstitute with 100 ul sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum. Store at -20C
• Purity: >95% (SDS-PAGE)
• Reference: IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis: C. De Salvo, et al.; Am. J. Pathol. (2016), Application(s): Experimental in Vivo Studies, Abstract;
  IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells: S. Ali, et al.; PNAS 104, 18660 (2007), Abstract;
  General Literature References
  IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005), Abstract;

Target Info

• Gene Symbol: Il33
• Gene Full Name: interleukin 33
• Alias Symbols: 9230117N10Rik;Il-;Il1f;Il1f11;Il-33;interleukin-33;NF-H;NF-HEV;nuclear factor from high endothelial venules.
• NCBI Gene Id: 77125
• Protein Name: Interleukin-33
• Description of Target: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury.
• Uniprot ID: Q8BVZ5
• Protein Accession #: NP_066289.3
• Nucleotide Accession #: NM_021009.6
• Protein Size (# AA): Recombinant
• Molecular Weight: 18 kDa