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IL28RA antibody - N-terminal region (ARP48069_P050)

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100 ul
$319.00
In Stock
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Conjugation Options

ARP48069_P050-FITC Conjugated

ARP48069_P050-HRP Conjugated

ARP48069_P050-Biotin Conjugated

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Gene Symbol:
IFNLR1
NCBI Gene Id:
163702
Official Gene Full Name:
Interleukin 28 receptor, alpha (interferon, lambda receptor)
Protein Name:
Interleukin-28 receptor subunit alpha
Swissprot Id:
Q5VTX8
Protein Accession #:
NP_775087
Nucleotide Accession #:
NM_173064
Alias Symbols:
CRF2/12, IFNLR, IFNLR1, LICR2, il-28r1, IL-28R1, IL28RA
Description of Target:
IL28RA belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Protein Size (# AA):
491
Molecular Weight:
54kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express IL28RA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express IL28RA.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human IL28RA
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 92%; Dog: 100%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 77%; Rabbit: 86%; Rat: 92%
Complete computational species homology data:
Anti-IL28RA (ARP48069_P050)
Peptide Sequence:
Synthetic peptide located within the following region: EECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYLF
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
IFNLR1; IFNL1; IFNL2; LSM8;
Blocking Peptide:
For anti-IFNLR1 (ARP48069_P050) antibody is Catalog # AAP48069 (Previous Catalog # AAPS21112)
Datasheets/Manuals:
Printable datasheet for anti-IFNLR1 (ARP48069_P050) antibody
Subunit:
alpha
Target Reference:
Chae,S.C., (2006) Exp. Mol. Med. 38 (3), 302-309
Publications:

Mucha, J., Majchrzak, K., Taciak, B., Hellmén, E. & Król, M. MDSCs mediate angiogenesis and predispose canine mammary tumor cells for metastasis via IL-28/IL-28RA (IFN-λ) signaling. PLoS One 9, e103249 (2014). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat 25075523

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