IL28RA Antibody - C-terminal region (OAAB15527)

Catalog No: OAAB15527

Size:400ul

IL28RA Antibody (C-term) (Cat. # OAAB15527) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IL28RA antibody detected the IL28RA protein (arrow).

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
• Additional Information: Function: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
  Cellular Location: Membrane; Single-pass type I membrane protein.
  Tissue Location: Widely expressed.
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This IL28RA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 485-513 amino acids of human IL28RA.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: 0.5 mg/ml
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: IFNLR1
• Alias Symbols: IFNLR, LICR2, IL28RA, CRF2/12, IL-28R1
• NCBI Gene Id: 163702
• Protein Name: Interleukin-28 receptor subunit alpha
• Description of Target: The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Uniprot ID: Q8IU57
• Protein Accession #: NP_734464.1
• Molecular Weight: 58 kDa