Catalog No: OPCA01661
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Datasheets/ManualsPrintable datasheet for IL1B Recombinant Protein (Sheep) (OPCA01661) (OPCA01661)
Product Info
Predicted Species ReactivityOvis aries|Sheep
Product FormatLiquid or Lyophilized powder
Additional InformationRelevance: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Reconstitution and Storage-20°C or -80°C
Formulation20 mM Tris-HCl based buffer, pH 8.0
PurityGreater than 90% as determined by SDS-PAGE.
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Protein Range114-266 aa
TagN-terminal 6xHis-tagged
ReferenceMolecular cloning and characterization of ovine IL-1 alpha and IL-1 beta.Andrews A.E., Barcham G.J., Brandon M.R., Nash A.D.Immunology 74:453-460(1991)
Gene SymbolIL1B
Gene Full Nameinterleukin 1 beta
Alias SymbolsIL-1 beta;IL-1B;interleukin-1 beta.
NCBI Gene Id443539
Protein NameInterleukin-1 beta
Description of TargetPotent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.
Uniprot IDP21621
Protein Accession #NP_001009465.2
Nucleotide Accession #NM_001009465.2
Protein Size (# AA)Recombinant
Molecular Weight21.7 kDa
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