IL13 Antibody - C-terminal region (OAAB10037)

Catalog No: OAAB10037

Size:400ul

IL13 Antibody (C-term) (Cat. #OAAB10037) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IL13 antibody detected the IL13 protein (arrow).

IL13 Antibody (C-term) (OAAB10037)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IL13 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Confocal immunofluorescent analysis of IL13 Antibody (C-term) with OAAB10037 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IF, IHC-P
• Additional Information: Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages
  Cellular Location: Secreted.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This IL13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-146 amino acids from the C-terminal region of human IL13.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: 0.4 mg/ml
• Intended Use: For research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:1000
  IF: 1:10~50
  IHC-P: 1:10~50
• Description:
  View product citations for IL13 Antibody - C-terminal region (OAAB10037) on CiteAb

Target Info

• Gene Symbol: IL13
• Alias Symbols: P600, IL-13
• NCBI Gene Id: 3596
• Protein Name: Interleukin-13
• Description of Target: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
• Uniprot ID: P35225
• Protein Accession #: NP_002179.2
• Molecular Weight: 16 kDa