Catalog No: OPTA00929
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Datasheets/Manuals | Printable datasheet for OPTA00929 |
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Tested Species Reactivity | Human |
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Product Format | Lyophilized |
Application | CA |
:: | Bioactivity: No data available at this time. |
:: | Endotoxin Level: Endotoxin level is <0.1 ng/ug of protein (<1 EU/ug). |
Reconstitution and Storage | -20C |
Purity | 98% |
Protein Sequence | p40 Subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ |
Source | CHO cells |
Reference | Gee K, Guzzo C, Che Mat NF, Ma W and Kumar A. 2009. Inflamm Allergy Drug Targets. 8(1): 40-52. Brombacher F, Kastelein RA and Alber G. Trends Immunol. 2003. 24(4): 207-212. Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, et al. Immunity. 2000. 13(5): 715-725. Holscher C. 2004. Med Microbiol Immunol. 193(1): 1-17. |
Gene Symbol | IL12B |
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Gene Full Name | interleukin 12B |
Alias Symbols | CLMF, NKSF, CLMF2, IMD28, IMD29, NKSF2, IL-12B |
NCBI Gene Id | 3593 |
Protein Name | interleukin-12 subunit beta |
Description of Target | This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. |
Molecular Weight | 40 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
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