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Catalog No: OPTA00929
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OPTA00929
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IL12B Protein (OPTA00929)

Datasheets/ManualsPrintable datasheet for OPTA00929
Product Info
Tested Species ReactivityHuman
Product FormatLyophilized
ApplicationCA
::Bioactivity: No data available at this time.
::Endotoxin Level: Endotoxin level is <0.1 ng/ug of protein (<1 EU/ug).
Reconstitution and Storage-20C
Purity98%
Protein Sequencep40 Subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ
SourceCHO cells
Reference

Gee K, Guzzo C, Che Mat NF, Ma W and Kumar A. 2009. Inflamm Allergy Drug Targets. 8(1): 40-52.

Brombacher F, Kastelein RA and Alber G. Trends Immunol. 2003. 24(4): 207-212.

Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, et al. Immunity. 2000. 13(5): 715-725.

Holscher C. 2004. Med Microbiol Immunol. 193(1): 1-17.

Gene SymbolIL12B
Gene Full Nameinterleukin 12B
Alias SymbolsCLMF, NKSF, CLMF2, IMD28, IMD29, NKSF2, IL-12B
NCBI Gene Id3593
Protein Nameinterleukin-12 subunit beta
Description of TargetThis gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Molecular Weight40 kDa
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