IL 32A Protein (OPPA01932)

Catalog No: OPPA01932 (Formerly GWB-B11CB0)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid 20mM Tris-HCl (pH 8), 1mM DTT and 10% glycerol
• Host: E. Coli
• Reconstitution and Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
• Purification: Purified by conventional chromatography.
• Concentration: 1 mg/ml
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Peptide Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMCF PKVLSDDMKK LKARMHQAIE RFYDKMQNAE SGRGQVMSSL AELEDDFKEGYLETVAAYYE EQHPELTPLL EKERDGLRCR GNRSPVPDVE DPATEEPGES FCDKSYGAPR GDKEELTPQK CSEPQSSK.
• Protein Range: 1-131aa
• Tag: N-terminal His tag

Target Info

• Gene Symbol: IL 32A His Tag
• Alias Symbols: NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, IL-32beta, IL-32alpha, IL-32delta, IL-32gamma
• NCBI Gene Id: 9235
• Protein Name: Interleukin-32
• Description of Target: IL-32 is part of the cytokine family and contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. IL-32 expression is elevated after the activation of T-cells by mitogens or the activation of NK cells by IL-2. IL-32 induces the production of TNF-a from macrophage cells. IL-32 pro-inflammatory pathway is activated in response to influenza A virus infection. Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. Induction of TNF, IL-1beta, and IL-6 by IL-32 is intervened by p38-MAPK. IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic, caspase-3-dependent mechanisms. IL32 plays an important role in the pathogenesis of rheumatoid arthritis. IL-32 is involved in activation-induced cell death in T cells, through its intracellular actions. IL-32 is a cell-associated proinflammatory cytokine, which is particularly stimulated by mycobacteria through a caspase-1- and IL-18-dependent production of interferon gamma.IL-32 is associated with TNF-a, IL-1beta, and IL-18. IL32 is involved in human rheumatoid arthritis and is a novel target in autoimmune diseases.
• Uniprot ID: P24001
• Protein Accession #: NP_001012649.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 19 kDa