IL-17 Antibody (OAPB00780)

Catalog No: OAPB00780

Size:100UG

Western blot analysis of IL-17 in THP-1 cell lysate with IL-17 antibody at (A) 1 and (B) 2 ug/mL. g/ml.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid. IL-17 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Western blot
• Reconstitution and Storage: IL-17 antibody can be stored at 4C for three months and -20C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: IL-17 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human IL-17A. The immunogen is located within amino acids 40 - 90 of IL-17.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-IL-17 antibody is Catalog # OEPB02902
• Application Info: IL-17 antibody can be used for the detection of IL-17 by Western blot at 1 - 2 ug/mL. Optimal dilution should be determined by user.
• Reference: Miossec P. Are T cells in rheumatoid synovium aggressors or bystanders? Curr. Opin. Rheumatol.2000; 12:181-5.;
  Paunovic V, Carroll HP, Vandenbroeck K, et al. Crossed signals: the role of interleukin (IL)-12, -17, -23, and -27 in autoimmunity. Rheumatol.2008; 47:771-6.;
  Steinman L. A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell-mediated tissue damage. Nat. Med.2007; 13:139-145.;

Target Info

• Gene Symbol: IL17A
• Gene Full Name: interleukin 17A
• Alias Symbols: CTLA8;CTLA-8;cytotoxic T-lymphocyte-associated antigen 8;cytotoxic T-lymphocyte-associated protein 8;IL17;IL-17;IL-17A;ILA17;interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8);interleukin-17;interleukin-17A.
• NCBI Gene Id: 3605
• Protein Name: Interleukin-17A|interleukin-17A precursor [Homo sapiens]
• Description of Target: Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
• Uniprot ID: Q16552
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_002181
• Molecular Weight: Predicted: 17.5kD Observed: 20 kD (Post-modification: 1 N-linked glycosylation)