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Catalog No: OAAB16435
Size:400ul
Price: $450.00
SKU
OAAB16435
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OAAB16435
Product Info
Predicted Species ReactivityHuman
Product FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationDB
Additional InformationPrecautions: IKKB Antibody (Phospho Y609) is for research use only and not for use in diagnostic or therapeutic procedures.
::Function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation
::Cellular Location: Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts
Tissue Location: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis IKKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y609 of human IKKB.
Predicted Homology Based on Immunogen SequenceHuman
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Application InfoDB: 1:500
Gene SymbolIKBKB
Alias SymbolsIKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB, IKK-beta
NCBI Gene Id3551
Protein NameInhibitor of nuclear factor kappa-B kinase subunit beta
Description of TargetPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Uniprot IDO14920
Protein Accession #NP_001177649.1
Molecular Weight86564 Da
  1. What is the species homology for "IKKB Antibody (Phospho-Tyr609) (OAAB16435)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "IKKB Antibody (Phospho-Tyr609) (OAAB16435)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "IKKB Antibody (Phospho-Tyr609) (OAAB16435)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "IKKB Antibody (Phospho-Tyr609) (OAAB16435)"?

    This target may also be called "IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB, IKK-beta" in publications.

  5. What is the shipping cost for "IKKB Antibody (Phospho-Tyr609) (OAAB16435)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "IKKB Antibody (Phospho-Tyr609) (OAAB16435)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "IKKB Antibody (Phospho-Tyr609) (OAAB16435)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "86564 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "IKKB Antibody (Phospho-Tyr609) (OAAB16435)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "IKBKB"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "IKBKB"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "IKBKB"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "IKBKB"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "IKBKB"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "IKBKB"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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