IgG1 Antibody (OAAF05805)

Catalog No: OAAF05805

Size:100 ug

Western blot analyzes of IgG1 antibody in extracts from LOVO cells.

Immunohistochemistry analyzes of IgG1 antibody in paraffin-embedded human lung carcinoma tissue.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human IgG1.
• Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
• Concentration: 1 mg/ml
• Specificity: IgG1 antibody detects endogenous levels of IgG1.
• Application Info: WB 1:500~1000
  IHC 1:50~100
  ELISA 1:10000
  

Target Info

• Gene Symbol: IGHG1
• Gene Full Name: immunoglobulin heavy constant gamma 1 (G1m marker)
• Alias Symbols: constant region of heavy chain of IgG1;Ig gamma-1 chain C region;Ig gamma-1 chain C region EU;Ig gamma-1 chain C region KOL;Ig gamma-1 chain C region NIE;immunoglobulin gamma 1 (Gm marker).
• NCBI Gene Id: 3500
• Protein Name: Immunoglobulin heavy constant gamma 1
• Description of Target: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
• Uniprot ID: P01857
• Molecular Weight: 36 kda