- Toll Free: 888-880-0001
- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for anti-IGF2BP1 (OAAJ06910) antibody |
---|
Tested Species Reactivity | Human, Mouse, Rat |
---|---|
Product Format | Liquid PBS (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Application | WB, IHC |
Additional Information | Subcellular Location: Nucleus. Cytoplasm. Cell projection > lamellipodium. Cell projection > dendrite. Cell projection > dendritic spine. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Targeted to stress granules (SGs), but not processing bodies (PBs), during cellular stress. Colocalizes with G3BP1 and TIAL1 in SGs. Colocalizes with HIV-1 GAG at the cell edges. Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Colocalized with H19 RNA at lamellipodia. Colocalized with CD44 mRNA in RNP granules. Nuclear export is mediated by XPO1/CRM1. In motile cells, is transported towards the leading edge into the cortical region of the lamellipodia where it is connected to microfilaments. Present in the form of granules and into F-actin-rich protrusion of dendrites, spines and subsynaptic sites (By similarity). Colocalizes with beta-actin mRNA in dendrites and spines. Exhibited rapid, bidirectional movements in dendrites and spines. Neuronal depolarization by KCl induces its rapid efflux from the cell body into dendrites. Tissue Specificity: Mainly expressed in the embryo, including in fetal liver, fetal lung, fetal kidney, fetal thymus (at protein level). Also expressed follicles of ovary, as well as in gonocytes of testis, spermatogonia, semen, oocytes and placenta (at protein level). Expressed in various cancers, including testis and lung cancers (at protein level), as well as kidney, prostate and trachea cancers. |
Reconstitution and Storage | Store at -20°C. Stable for 12 months from date of receipt. |
Immunogen | A synthetic peptideof human IGF2BP1, corresponding to a region within N terminal amino acids. |
Purification | Peptide affinity chromatography |
Predicted Homology Based on Immunogen Sequence | Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%) |
Concentration | 1 mg/mL |
Specificity | IGF2BP1 Antibody detects endogenous levels of total IGF2BP1. |
Application Info | WB: 1:500~2000 IHC: 1:50~200 |
Gene Symbol | IGF2BP1 |
---|---|
Alias Symbols | IMP1, ZBP1, CRDBP, IMP-1, CRD-BP, VICKZ1 |
NCBI Gene Id | 10642 |
Protein Name | Insulin-like growth factor 2 mRNA-binding protein 1 |
Description of Target | Insulin-like growth factor-II mRNA-binding proteins (IMPs) belong to a family of zipcode-binding proteins. Three members of this family, IMP1, IMP2, and IMP3, have been identified. They contain two RNA recognition motifs, four K homology domains, and were found to function in mRNA localization, turnover, and translation control. Research studies have implicated these proteins in a variety of physiological and pathological processes, such as growth and development, testicular neoplasia, and melanocytic neoplasia. |
Uniprot ID | Q9NZI8 |
Protein Accession # | NP_001153895 |
Nucleotide Accession # | NM_001160423 |
Molecular Weight | 63 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
See our General FAQ page.
-
What is the species homology for "IGF2BP1 Antibody (OAAJ06910)"?
The tested species reactivity for this item is "Human, Mouse, Rat". This antibody is predicted to have homology to "".
-
How long will it take to receive "IGF2BP1 Antibody (OAAJ06910)"?
This item is available "Domestic: within 2-3 week delivery | International: 2-3 weeks".
-
What buffer format is "IGF2BP1 Antibody (OAAJ06910)" provided in?
This item is provided in "Liquid PBS (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol ".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "IGF2BP1 Antibody (OAAJ06910)"?
This target may also be called "IMP1, ZBP1, CRDBP, IMP-1, CRD-BP, VICKZ1" in publications.
-
What is the shipping cost for "IGF2BP1 Antibody (OAAJ06910)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
-
What is the guarantee for "IGF2BP1 Antibody (OAAJ06910)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "IGF2BP1 Antibody (OAAJ06910)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "63 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "IGF2BP1 Antibody (OAAJ06910)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "IGF2BP1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "IGF2BP1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "IGF2BP1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "IGF2BP1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "IGF2BP1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "IGF2BP1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.