IGF1R Antibody - Biotin Conjugated (OACA01558)

Catalog No: OACA01558

Size:100ug

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Biotin
• Application: Enzyme-linked immunosorbent assay
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Insulin-like growth factor I protein (49-118AA)
• Purification: Protein G Purified
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Reference: [1] Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.'Ullrich A., Gray A., Tam A.W., Yang-Feng T., Tsubokawa M., Collins C., Henzel W., Bon T.L., Kathuria S., Chen E., Jacobs S., Francke U., Ramachandran J., Fujita-Yamaguchi Y.EMBO J. 5:2503-2512(1986)
  [2] Insulin-like growth factor I receptor gene structure.'Abbot A.M., Bueno R., Pedrini M.T., Murray J.M., Smith R.J.J. Biol. Chem. 267:10759-10763(1992)
  [3] Nagase T., Kikuno R.F., Yamakawa H., Ohara O.Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE
  [LARGE SCALE MRNA] Tissue: Fetal brain.
• Storage Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: IGF1
• Gene Full Name: insulin like growth factor 1
• Alias Symbols: IGF;IGFI;IGF-I;insulin-like growth factor 1 (somatomedin C);insulin-like growth factor I;insulin-like growth factor IB;mechano growth factor;MGF;somatomedin-C.
• NCBI Gene Id: 3479
• Protein Name: Insulin-like growth factor I
• Description of Target: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309).
• Uniprot ID: P05019