IFNLR1 Antibody - middle region (OASG03820)

Catalog No: OASG03820

Size:100 uL

Western Blot

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB
  Tissue Specificity: Widely expressed.
  Cellular Localization: Membrane
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the Internal region of human IL-28R Alpha.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: IL-28R Alpha Polyclonal Antibody detects endogenous levels of IL-28R Alpha protein.
• Application Info: WB: 1:500~2000
  ELISA: 1:40000

Target Info

• Gene Symbol: IFNLR1
• Gene Full Name: interferon, lambda receptor 1
• Alias Symbols: IFNLR, LICR2, IL28RA, CRF2/12, IL-28R1
• NCBI Gene Id: 163702;
• Description of Target: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
• Uniprot ID: Q8IU57
• Molecular Weight: 58 kDa