IFNLR1 Antibody - middle region (OAAB19332)

Catalog No: OAAB19332

Size:400ul

Anti-IL28RA Antibody (Center)at 1: 2000 dilution + Ramos whole cell lysates
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution
Predicted band size: 58 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB, E
• Additional Information: Cellular Location: Membrane; Single-pass type I membrane protein
  Tissue Location: Widely expressed
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This IL28RA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 387-420 amino acids from the Central region of human IL28RA.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: 0.5 mg/ml
• Intended Use: For research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:2,000
  Optimal dilutions should be determined by the end user.
• Reference: Dumoutier L.,et al.Biochem. J. 370:391-396(2003).
  Sheppard P.,et al.Nat. Immunol. 4:63-68(2003).
  Kotenko S.V.,et al.Nat. Immunol. 4:69-77(2003).
  Ota T.,et al.Nat. Genet. 36:40-45(2004).
  Gregory S.G.,et al.Nature 441:315-321(2006).

Target Info

• Gene Symbol: IFNLR1
• Alias Symbols: IFNLR, LICR2, IL28RA, CRF2/12, IL-28R1
• NCBI Gene Id: 163702
• Description of Target: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
• Uniprot ID: Q8IU57
• Molecular Weight: 58 kDa