IDN3 CONTROL PEPTIDE (OERA00071)

Catalog No: OERA00071

Size:50UG

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Liquid (sterile filtered)
• Conjugation: Unconjugated
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Concentration: 1 mg/ml

Target Info

• Gene Symbol: NIPBL
• Gene Full Name: NIPBL cohesin loading factor
• Alias Symbols: CDLS;CDLS1;delangin;IDN3;IDN3-B;Nipped-B homolog;nipped-B-like protein;Scc2;SCC2 homolog;sister chromatid cohesion 2 homolog.
• NCBI Gene Id: 25836
• Protein Name: Nipped-B-like protein
• Description of Target: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitement to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitement to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity).
• Uniprot ID: Q6KC79