Size:100 ul
Special Price $229.00 Regular Price $319.00
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ARP48207_P050
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Conjugation Options

ARP48207_P050-FITC Conjugated

ARP48207_P050-HRP Conjugated

ARP48207_P050-Biotin Conjugated

More Information
Tested Species Reactivity Human, Mouse, Rat
Predicted Species Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-134923 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human IDH2
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 93%; Zebrafish: 100%
Complete computational species homology data Anti-IDH2 (ARP48207_P050)
Peptide Sequence Synthetic peptide located within the following region: GGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFK
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-IDH2 (ARP48207_P050) antibody is Catalog # AAP48207 (Previous Catalog # AAPS22805)
Datasheets/Manuals Printable datasheet for anti-IDH2 (ARP48207_P050) antibody
Target Reference Shin,S.W., (2008) Biochem. Biophys. Res. Commun. 366 (4), 1012-1018
Publications

Vohwinkel, C. U. et al. Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation. J. Biol. Chem. 286, 37067-76 (2011). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish 21903582

Gene Symbol IDH2
Official Gene Full Name Isocitrate dehydrogenase 2 (NADP+), mitochondrial
Alias Symbols ICD-M, IDH, IDHM, IDP, mNADP-IDH, IDPM, D2HGA2
NCBI Gene Id 3418
Protein Name Isocitrate dehydrogenase [NADP], mitochondrial
Description of Target Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. IDH2 is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot Id P48735
Protein Accession # NP_002159
Nucleotide Accession # NM_002168
Protein Size (# AA) 452
Molecular Weight 47kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express IDH2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express IDH2.
Protein Interactions UBC; SUMO1; NEDD8; MDM2; ADRB2; HDAC1; PYGL; CDK2; SLC2A4;
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