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IDH2 antibody - middle region (ARP48207_P050)

100 ul
$319.00
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Conjugation Options

ARP48207_P050-FITC Conjugated

ARP48207_P050-HRP Conjugated

ARP48207_P050-Biotin Conjugated

Gene Symbol:
IDH2
NCBI Gene Id:
3418
Official Gene Full Name:
Isocitrate dehydrogenase 2 (NADP+), mitochondrial
Protein Name:
Isocitrate dehydrogenase [NADP], mitochondrial
Swissprot Id:
P48735
Protein Accession #:
NP_002159
Nucleotide Accession #:
NM_002168
Alias Symbols:
ICD-M, IDH, IDHM, IDP, mNADP-IDH, IDPM, D2HGA2
Replacement Item:
This antibody may replace item sc-134923 from Santa Cruz Biotechnology.
Description of Target:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. IDH2 is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
452
Molecular Weight:
47kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express IDH2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express IDH2.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human IDH2
Tested Species Reactivity:
Human, Mouse, Rat
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 93%; Zebrafish: 100%
Complete computational species homology data:
Anti-IDH2 (ARP48207_P050)
Peptide Sequence:
Synthetic peptide located within the following region: GGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFK
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; SUMO1; NEDD8; MDM2; ADRB2; HDAC1; PYGL; CDK2; SLC2A4;
Blocking Peptide:
For anti-IDH2 (ARP48207_P050) antibody is Catalog # AAP48207 (Previous Catalog # AAPS22805)
Datasheets/Manuals:
Printable datasheet for anti-IDH2 (ARP48207_P050) antibody
Target Reference:
Shin,S.W., (2008) Biochem. Biophys. Res. Commun. 366 (4), 1012-1018
Publications:

Vohwinkel, C. U. et al. Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation. J. Biol. Chem. 286, 37067-76 (2011). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish 21903582

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