Search Antibody, Protein, and ELISA Kit Solutions

ID4 Antibody - N-terminal region : HRP (ARP38058_T100-HRP)

100 ul
$249.00
In Stock
Request Bulk Order Quote

Conjugation Options

ARP38058_T100 Unconjugated

ARP38058_T100-FITC Conjugated

ARP38058_T100-Biotin Conjugated

Gene Symbol:
ID4
Official Gene Full Name:
Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
NCBI Gene Id:
3400
Protein Name:
DNA-binding protein inhibitor ID-4
Swissprot Id:
P47928
Protein Accession #:
NP_001537
Nucleotide Accession #:
NM_001546
Alias Symbols:
IDB4, bHLHb27
Replacement Item:
This antibody may replace item sc-13047 from Santa Cruz Biotechnology.
Description of Target:
Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995).[supplied by OMIM].
Protein Size (# AA):
161
Molecular Weight:
17kDa
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ID4.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ID4.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human ID4
Predicted Species Reactivity:
Dog, Human, Mouse, Pig, Rat, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 85%
Complete computational species homology data:
Anti-ID4 (ARP38058_T100)
Peptide Sequence:
Synthetic peptide located within the following region: MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAAAAAARC
Product Format:
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution and Storage:
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Concentration:
0.5 mg/ml
Protein Interactions:
TCF3; TCF4; ID3; MYOD1; HES1;
Blocking Peptide:
For anti-ID4 (ARP38058_T100-HRP) antibody is Catalog # AAP38058 (Previous Catalog # AAPP20232)
Datasheets/Manuals:
Printable datasheet for anti-ID4 (ARP38058_T100-HRP) antibody
Conjugation:
HRP
Target Reference:
Yu,L., et al., (2005) Nat. Genet. 37 (3), 265-274
Publications:

Melcher, R. et al. LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability. Carcinogenesis 32, 636-42 (2011). WB, IHC, Pig, Dog, Rat, Mouse, Human, Zebrafish 21297112

Product Reviews

Tell us what you think about this item!

Write A Review
    Please, wait...