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Now Offering Over 102,157 Antibodies & 44,722 Antigens!

ID4 antibody - N-terminal region (ARP38058_T100)

100 ul
$249.00
In Stock

Conjugation Options

ARP38058_T100-FITC Conjugated

ARP38058_T100-HRP Conjugated

ARP38058_T100-Biotin Conjugated

Gene Symbol:
ID4
NCBI Gene Id:
3400
Official Gene Full Name:
Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
Protein Name:
DNA-binding protein inhibitor ID-4
Swissprot Id:
P47928
Protein Accession #:
NP_001537
Nucleotide Accession #:
NM_001546
Alias Symbols:
IDB4, bHLHb27
Replacement Item:
This antibody may replace item sc-13047 from Santa Cruz Biotechnology.
Description of Target:
Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995).[supplied by OMIM].
Protein Size (# AA):
161
Molecular Weight:
17kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ID4.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ID4.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human ID4
Species Reactivity:
Dog, Human, Mouse, Pig, Rat, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 85%
Complete computational species homology data:
Anti-ID4 (ARP38058_T100)
Peptide Sequence:
Synthetic peptide located within the following region: MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAAAAAARC
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
TCF3; TCF4; ID3; MYOD1; HES1;
Blocking Peptide:
For anti-ID4 (ARP38058_T100) antibody is Catalog # AAP38058 (Previous Catalog # AAPP20232)
Datasheets/Manuals:
Printable datasheet for anti-ID4 (ARP38058_T100) antibody
Target Reference:
Yu,L., et al., (2005) Nat. Genet. 37 (3), 265-274
Publications:

Melcher, R. et al. LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability. Carcinogenesis 32, 636-42 (2011). WB, Dog, Human, Mouse, Pig, Rat, Zebrafish 21297112

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