ICMT Antibody - C-terminal region (OAAB15947)

Catalog No: OAAB15947

Size:400ul

The anti-ICMT Pab (Cat. # OAAB15947) is used in Western blot to detect ICMT in T47D (left) and SK-BR-3 (right) tissue lysate

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
  Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
  Cellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein.
  Tissue Location: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions Abundant expression seen in the Purkinje cells and pontine neurons.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This ICMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-284 amino acids from the C-terminal region of human ICMT.
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Concentration: 2 mg/ml
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: ICMT
• Alias Symbols: PCMT, PPMT, PCCMT, HSTE14, MST098, MSTP098
• NCBI Gene Id: 23463
• Protein Name: Protein-S-isoprenylcysteine O-methyltransferase
• Description of Target: This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing results in two transcript variants encoding different isoforms.
• Uniprot ID: O60725
• Protein Accession #: NP_036537.1
• Molecular Weight: 32 kDa