ICAM1 Antibody (OAEE00913)

Catalog No: OAEE00913

Size:100T

Product Info

• Predicted Species Reactivity: Human
• Product Format: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Clonality: Monoclonal
• Clone: 1H4
• Isotype: IgG2b
• Host: Mouse
• Conjugation: FITC
• Application: Flow cytometry
• Reconstitution and Storage: 2°C to 8°C
• Immunogen: Raji cells and spleen cells fused with NS1 cells
• Purification: Purified by size-exclusion chromatography
• Concentration: 20 ul / test
• Specificity: The antibody 1H4 reacts with CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus) expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells; the expression of CD54 is upregulated by activation.
• Formulation: FITC
• Storage Buffer: The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
• Reference: Williams DT, Chaudhry Y, Goodfellow IG, Lea S, Evans DJ.: Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites. J Gen Virol. 2004 Mar;85(Pt 3):731-8.
  Springer TA.: Adhesion receptors of the immune system.Nature. 1990 Aug 2;346(6283):425-34.
  Ockenhouse CF, Betageri R, Springer TA, Staunton DE.: Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus.Cell. 1992 Jan 10;68(1):63-9. Erratum in: Cell 1992 Mar 6;68(5):following 994.
  Boyd AW, Dunn SM, Fecondo JV, Culvenor JG, Duhrsen U, Burns GF, Wawryk SO.: Regulation of expression of a human intercellular adhesion molecule (ICAM-1) during lymphohematopoietic differentiation. Blood. 1989 May 15;73(7):1896-903.
  Boyd AW, Wawryk SO, Burns GF, Fecondo JV.: Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cellcontact-mediated immune mechanisms. Proc Natl Acad Sci U S A. 1988 May;85(9):3095-9.

Target Info

• Gene Symbol: ICAM1
• Gene Full Name: intercellular adhesion molecule 1
• Alias Symbols: BB2;CD54;cell surface glycoprotein P3.58;epididymis secretory sperm binding protein;ICAM-1;intercellular adhesion molecule 1;intercellular adhesion molecule 1 (CD54), human rhinovirus receptor;major group rhinovirus receptor;P3.58.
• NCBI Gene Id: 3383
• Protein Name: Intercellular adhesion molecule 1
• Description of Target: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
• Uniprot ID: P05362
• Protein Accession #: NP_000192.2
• Nucleotide Accession #: NM_000201.2