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ICA1 antibody - N-terminal region (ARP54742_P050)

100 ul
$289.00
In Stock

Conjugation Options

ARP54742_P050-FITC Conjugated

ARP54742_P050-HRP Conjugated

ARP54742_P050-Biotin Conjugated

Gene Symbol:
ICA1
NCBI Gene Id:
3382
Official Gene Full Name:
Islet cell autoantigen 1, 69kDa
Protein Name:
Islet cell autoantigen 1
Swissprot Id:
Q05084
Protein Accession #:
NP_004959
Nucleotide Accession #:
NM_004968
Alias Symbols:
ICA69, ICAp69
Replacement Item:
This antibody may replace item sc-27536 from Santa Cruz Biotechnology.
Description of Target:
ICA1 is a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Protein Size (# AA):
483
Molecular Weight:
55kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB, IHC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ICA1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ICA1.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human ICA1
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Complete computational species homology data:
Anti-ICA1 (ARP54742_P050)
Peptide Sequence:
Synthetic peptide located within the following region: SKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFS
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
RAB2B; ING5; MBD3; CCDC28A; RAB2A; tbc-8; EXOC5; STK16; MKKS; KRT33B; CNTF;
Blocking Peptide:
For anti-ICA1 (ARP54742_P050) antibody is Catalog # AAP54742 (Previous Catalog # AAPP31537)
Datasheets/Manuals:
Printable datasheet for anti-ICA1 (ARP54742_P050) antibody
Sample Type Confirmation:

There is BioGPS gene expression data showing that ICA1 is expressed in HepG2

Target Reference:
Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)

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