Catalog No: OOMC00066
Price: $0.00
SKU
OOMC00066
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/Manuals | Printable datasheet for OOMC00066 |
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Product Format | Powder |
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Additional Information | CAS: 1260907-17-2 Molecular Formula: C22H22ClN5O2 |
:: | Chemical Name: (4S)- 6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide |
:: | Primary Activity: Bromodomain (BET) inhibitor |
:: | COVID-19 Rationale: SARS-CoV-2 transmembrane protein E binds to the bromodomain-containing proteins BRD2 and BRD4 |
Reconstitution and Storage | Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml). Store at -20C. |
Purity | > 98% |
Reference | 1) Nicodeme et al. (2010), Suppression of inflammation by a synthetic histone mimic; Nature 468 1119 2) Mirguet et al. (2013), Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains; J.Med.Chem., 56 7501 3) Bandukwala et al. (2012), Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors; Proc.Natl.Acad.Sci.USA, 109 14532 4) Delmore et al. (2011), BET Bromodomain as a Therapeutic Strategy to Target c-Myc; Cell 146 904 |
Alias Symbols | GSK525762 |
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Molecular Weight | 423.90 g/mol |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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