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Catalog No: OOMC00066
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OOMC00066
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Datasheets/ManualsPrintable datasheet for OOMC00066
Product Info
Product FormatPowder
Additional InformationCAS: 1260907-17-2
Molecular Formula: C22H22ClN5O2
::Chemical Name: (4S)- 6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
::Primary Activity: Bromodomain (BET) inhibitor
::COVID-19 Rationale: SARS-CoV-2 transmembrane protein E binds to the bromodomain-containing proteins BRD2 and BRD4
Reconstitution and StorageSoluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml). Store at -20C.
Purity> 98%
Reference1) Nicodeme et al. (2010), Suppression of inflammation by a synthetic histone mimic; Nature 468 1119 2) Mirguet et al. (2013), Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains; J.Med.Chem., 56 7501 3) Bandukwala et al. (2012), Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors; Proc.Natl.Acad.Sci.USA, 109 14532 4) Delmore et al. (2011), BET Bromodomain as a Therapeutic Strategy to Target c-Myc; Cell 146 904
Alias SymbolsGSK525762
Molecular Weight423.90 g/mol
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