Hydroxychloroquine sulfate (OOMC00018)

Catalog No: OOMC00018

Product Info

• Product Format: Lyophilized White powder
• Additional Information: CAS: 747-36-4
  Molecular Formula: C₁₈H₂₆ClN₃O - H₂SO₄
  Chemical Name: 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinolone sulfate
• Reconstitution and Storage: Maybe dissolved in water (40 mg/ml) or DMSO (nil). Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
• Purity: > 98% (TLC); NMR (Conforms)
• Reference: 1) Boya et al. (2005), Inhibition of macroautophagy triggers apoptosis; Mol. Cell Biol., 25 1025 2) Xie et al. (2013), Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma; PLoS One, 8 e55096 3) Pan et al. (2011), Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy; Clin. Cancer Res., 150 3248 4) Jeong et al. (2002), Chloroquine decreases cell-surface expression of tumor necrosis factor receptors in human histiocytic U-937 cells; Immunology, 105 83 5) Stephan et al. (2013), Successful treatment of alopecia totalis wih hydroxychloroquine: report of 2 cases; J. Am. Acad. Dermatol., 68 1048

Target Info

• Description of Target: A lysosomotropic agent which inhibits autophagy and triggers apotosis in a variety of cell types. Augments the anticancer activity of DNA-damaging chemotherapy. Antiinflammatory activity. Decreases cell surface expression of TNF-alpha receptors in U937 cells. Has been used to treat alopecia successfully. Clinicial useful antimalara agent. Cell permeable and active in vivo.
• Molecular Weight: 434 Da