HVCN1 Antibody (OAPB01154)

Catalog No: OAPB01154

Size:100UG

Western blot analysis of HVCN1 in (A) human spleen and (B) mouse spleen tissue lysates with HVCN1 antibody at 1 ug/mL.

Product Info

• Predicted Species Reactivity: Chicken|Human|Mouse|Rat
• Product Format: Liquid. HVCN1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
  Positive Controls: mouse spleen tissue, human spleen tissue
• Reconstitution and Storage: HVCN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: HVCN1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human HVCN1. The immunogen is located within the last 50 amino acids of HVCN1.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Chicken (71%)
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-HVCN1 (OAPB01154) antibody is Catalog # OEPB03271
• Application Info: WB: 1 ug/mL
  IHC: 5 ug/mL
  IF: 20 ug/mL. Antibody validated: WB in human and mouse samples, IHC in rat samples, and IF in rat samples.
• Reference: Ramsey IS, Moran MM, Chong JA, et al. A voltage gated proton-selective channel lacking the pore domain. Nature2006; 440:1213-6.;
  Sasaki M, Takagi M, and Okamura Y. A voltage sensor-domain protein is a voltage-gated proton channel. Science2006; 312: 589-92.;
  Morgan D, Capasso M, and Musset B. Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc. Natl. Acad. Sci. USA2009; 106:18022-7.;
  Capasso M, Bhamrah MK, Henley T, et al. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat. Immunol.2010;11:265-72.
• Publications:

  Genetic variation of staphylococcal LukAB toxin determines receptor tropism. Nat Microbiol. 6, 731-745 (2021). 33875847

• Description:
  View product citations for HVCN1 Antibody (OAPB01154) on CiteAb

Target Info

• Gene Symbol: HVCN1
• Gene Full Name: hydrogen voltage gated channel 1
• Alias Symbols: HV1;Hydrogen voltage-gated channel 1;voltage sensor domain-only protein;voltage-gated hydrogen channel 1;VSOP.
• NCBI Gene Id: 84329
• Protein Name: Voltage-gated hydrogen channel 1|voltage-gated hydrogen channel 1 isoform 1 [Homo sapiens]
• Description of Target: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
• Uniprot ID: Q96D96
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_115745
• Nucleotide Accession #: NM_001040107.1; NM_001256413.1; NM_032369.3; XM_005253948.1
• Molecular Weight: Predicted: 30 kDa Observed: 30 kDa