Human PDGF BB HOMODIMER Protein (OPSA10941)

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Datasheets/Manuals	Printable datasheet for Human PDGF BB HOMODIMER Protein (OPSA10941)

Product Info

Product Info
Predicted Species Reactivity	Human
Product Format	Lyophilized. 30 mM Acetic Acid
Application	Enzyme-linked immunosorbent assay\|Functional assay\|Western blot
Additional Information	Approx Protein Conc: Total protein concentration 1.0 mg/ml after reconstitution. Buffer solution: 10 mM Acetic Acid
::	Endotoxin Level: < 0.1ng/ug
::	Preservative: None present
Reconstitution and Storage	-20°C
Predicted Homology Based on Immunogen Sequence	Human
Concentration	0.1 mg/ml
Purity	>98% by SDS PAGE and HPLC analysis
Application Info	Functional Assays: 0.2ng/ml - 10ng/ml

Target Info

Gene Symbol	PDGFB
Alias Symbols	SIS, SSV, IBGC5, PDGF2, c-sis, PDGF-2
NCBI Gene Id	5155
Protein Name	Platelet-derived growth factor subunit B
Description of Target	RECOMBINANT HUMAN PDGF BB HOMODIMER
Uniprot ID	P01127
Protein Accession #	NP_002599.1
Protein Size (# AA)	Recombinant

Protocols & Data

Protocol:

Tips Information:

See our General FAQ page.

Protein interactions

Name	# of Products
A2M	261
ART1	7
COL1A1	128
HRAS	211
HSPG2	69
LRP1	227
PDAP1	16
PDGFB	59
PDGFRA	83
PDGFRB	128
SPARC	118
THBS1	221

Biological pathways

Name	# of Products
Activation of protein kinase B activity	71
Cellular response to mycophenolic acid	15
Embryonic placenta development	25
Heart development	92
Metanephric glomerular mesangial cell development	8
Monocyte chemotaxis	65
Negative regulation of phosphatidylinositol biosynthetic process	13
Negative regulation of platelet activation	62
Negative regulation of transcription, DNA-dependent	660
Paracrine signaling	8
Peptidyl-serine phosphorylation	97
Peptidyl-tyrosine phosphorylation	165
Platelet activation	875
Platelet degranulation	443
Positive regulation of blood vessel endothelial cell migration	76
Positive regulation of calcium ion import	15
Positive regulation of cell division	223
Positive regulation of chemotaxis	23
Positive regulation of cyclin-dependent protein kinase activity	33
Positive regulation of DNA biosynthetic process	23
Positive regulation of DNA replication	222
Positive regulation of endothelial cell proliferation	175
Positive regulation of ERK1 and ERK2 cascade	194
Positive regulation of fibroblast proliferation	119
Positive regulation of glomerular filtration	8
Positive regulation of glomerular mesangial cell proliferation	8
Positive regulation of MAP kinase activity	147
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	19
Positive regulation of mitosis	179
Positive regulation of peptidyl-tyrosine phosphorylation	308
Positive regulation of phosphatidylinositol 3-kinase activity	98
Positive regulation of phosphatidylinositol 3-kinase cascade	210
Positive regulation of protein autophosphorylation	71
Positive regulation of protein tyrosine kinase activity	27
Positive regulation of reactive oxygen species metabolic process	55
Positive regulation of smooth muscle cell migration	54
Positive regulation of smooth muscle cell proliferation	123
Positive regulation of transcription, DNA-dependent	694
Reactive oxygen species metabolic process	36
Transforming growth factor beta receptor signaling pathway	171

Biological process

Name	# of Products
Activation of protein kinase activity	27
Activation of protein kinase B activity	12
Blood coagulation	396
Cell chemotaxis	24
Cell growth	42
Cellular response to mycophenolic acid	4
Embryonic placenta development	31
Heart development	186
Hemopoiesis	78
Metanephric glomerular mesangial cell development	2
Monocyte chemotaxis	23
Multicellular organismal development	896
Negative regulation of phosphatidylinositol biosynthetic process	4
Negative regulation of platelet activation	10
Negative regulation of transcription, DNA-dependent	520
Paracrine signaling	4
Peptidyl-serine phosphorylation	61
Peptidyl-tyrosine phosphorylation	72
Platelet activation	202
Platelet degranulation	78
Platelet-derived growth factor receptor signaling pathway	27
Positive regulation of blood vessel endothelial cell migration	24
Positive regulation of calcium ion import	9
Positive regulation of cell division	67
Positive regulation of cell migration	150
Positive regulation of cell proliferation	483
Positive regulation of chemotaxis	14
Positive regulation of cyclin-dependent protein kinase activity	11
Positive regulation of DNA biosynthetic process	8
Positive regulation of DNA replication	56
Positive regulation of endothelial cell proliferation	68
Positive regulation of ERK1 and ERK2 cascade	103
Positive regulation of fibroblast proliferation	47
Positive regulation of glomerular filtration	2
Positive regulation of glomerular mesangial cell proliferation	3
Positive regulation of MAP kinase activity	56
Positive regulation of MAPK cascade	81
Positive regulation of metanephric mesenchymal cell migration	2
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	7
Positive regulation of mitosis	50
Positive regulation of peptidyl-tyrosine phosphorylation	112
Positive regulation of phosphatidylinositol 3-kinase activity	39
Positive regulation of phosphatidylinositol 3-kinase cascade	60
Positive regulation of protein autophosphorylation	18
Positive regulation of protein tyrosine kinase activity	17
Positive regulation of reactive oxygen species metabolic process	31
Positive regulation of smooth muscle cell migration	26
Positive regulation of smooth muscle cell proliferation	67
Positive regulation of transcription, DNA-dependent	681
Protein phosphorylation	451
Reactive oxygen species metabolic process	23
Response to drug	323
Response to estradiol stimulus	102
Response to hypoxia	205
Response to insulin stimulus	68
Response to organic cyclic compound	128
Response to wounding	70
Transforming growth factor beta receptor signaling pathway	95

Cellular components

Name	# of Products
Basolateral plasma membrane	122
Cell surface	369
Cytoplasm	4549
Endoplasmic reticulum lumen	87
Extracellular region	1573
Golgi membrane	308
Membrane	2769
Platelet alpha granule lumen	42

Protein function

Name	# of Products
Cell surface binding	163
Collagen binding	197
Eukaryotic cell surface binding	205
Growth factor activity	831
Platelet-derived growth factor binding	66
Platelet-derived growth factor receptor binding	96
Protein binding	12191
Protein heterodimerization activity	1132
Protein homodimerization activity	1852
Protein tyrosine kinase activity	369
Superoxide-generating NADPH oxidase activator activity	11

Diseases

Name	# of Products
Proto-oncogene	793

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Human PDGF BB HOMODIMER Protein (OPSA10941)

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