Human PAI-1 Protein (OPSA11046)

Catalog No: OPSA11046 (Formerly GWB-4DF28B)

Size:10UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized. 10mM Sodium Phosphate
• Application: Functional assay
• Additional Information: Activity: Determined by its inhibitory effect against single chain tPA induced cleavage of a chromogenic substrate in Imidazole Buffer at 37^oC. Half maximal inhibition against 1.0 ug/ml of single chain tPA was obtained at a concentration of 2.0 ug/ml.
  Approx Protein Conc: 0.1mg/ml
  Endotoxin Level: < 1EU/ug
  Label Protein Molar Ratio: Purified recombinant PAI-1 expressed in E.coli.
  Preservative: None present
• Reconstitution and Storage: -20°C
• Predicted Homology Based on Immunogen Sequence: Human
• Purification: Purified recombinant PAI-1 expressed in E.coli.
• Concentration: 0.1 mg/ml
• Purity: >98% by SDS PAGE and HPLC analysis.
• Specificity: PAI-1 (plasminogen activator inhibitor-1) is a serine protease inhibitor and member of the serpin family, which acts as the primary inhibitor of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), and hence fibrinolysis.
  Increased levels of PAI-1 are associated with diabetes, cardiovascular disease and an increased occurrence of thrombosis in obesity, and can be induced by obesity related factors including insulin, glucose and VLDL (very-low-density lipoprotein).
  

Target Info

• Gene Symbol: SERPINE1
• Alias Symbols: PAI, PAI1, PAI-1, PLANH1
• NCBI Gene Id: 5054
• Protein Name: Plasminogen activator inhibitor 1
• Description of Target: RECOMBINANT HUMAN PAI-1
  
• Uniprot ID: P05121
• Protein Accession #: NP_000593.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 42.7kD (379 amino acid residues).