Human INSULIN-LIKE GROWTH FACTOR I Protein (OPSA11026)

Catalog No: OPSA11026 (Formerly GWB-BA0D90)

Size:100UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized
• Application: Functional assay
• Additional Information: Activity: The ED₅₀ was determined by a cell proliferation assay using FDC-P1 cells is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 10⁵ units/mg.
  Approx Protein Conc: 0.1mg/ml
  Endotoxin Level: < 1EU/ug
  Label Protein Molar Ratio: Purified recombinant IGF-I expressed in E.coli.
  Preservative: None present
• Reconstitution and Storage: -20°C
• Predicted Homology Based on Immunogen Sequence: Human
• Purification: Purified recombinant IGF-I expressed in E.coli
• Concentration: 0.1 mg/ml
• Purity: >98% by SDS PAGE/HPLC analysis.
• Specificity: IGF-I (Insulin-like Growth Factor I), is a secreted mitogenic polypeptide and member of the insulin gene family, produced primarily by the liver, which effects a wide range of cells and plays a key role in cell proliferation and growth, inhibition of apoptosis, and is linked with tumour cell growth.
  IGF-I signals through binding to the type 1 insulin-like growth factor receptor (IGF-1R) and also to the insulin receptor (IR), resulting in the activation of the AKT signalling pathway. IGF-I production is stimulated by growth hormone (GH). and can be hindered by GH insensitivity, deficiency in GH receptors or a malfunction in the post GH receptor signalling pathway.
  

Target Info

• Gene Symbol: IGF1
• Alias Symbols: IGF, MGF, IGFI, IGF-I
• NCBI Gene Id: 3479
• Protein Name: Insulin-like growth factor I
• Description of Target: RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR I
  
• Uniprot ID: P01343
• Protein Accession #: NP_001104755.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 7.6kD