Human CD120b Protein (OPSA11061)

Catalog No: OPSA11061 (Formerly GWB-B2A64C)

Size:20UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized. Phosphate buffered saline.
• Application: Enzyme-linked immunosorbent assay|Functional assay|Western blot
• Additional Information: Activity: Determined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in murine L-929 cells. The ED₅₀ for this effect in the presence of 0.25 ng/ml of recombinant human TNF-alpha is 0.125 ug/ml.
  Approx Protein Conc: 0.1mg/ml
  Endotoxin Level: < 1EU/ug
  Label Protein Molar Ratio: Purified recombinant CD120b expressed in E.coli
  Preservative: None present
• Reconstitution and Storage: -20°C
• Predicted Homology Based on Immunogen Sequence: Human
• Purification: Purified recombinant CD120b expressed in E.coli
• Concentration: 0.1 mg/ml
• Purity: >98% by SDS PAGE and HPLC analysis
• Specificity: The soluble form of human CD120b, otherwise known as sTNF receptor type II (sTNFRII), is a member of the tumour necrosis factor receptor (TNFR) superfamily, produced by proteolytic cleavage of the membrane form by the metalloprotease TACE.
  CD120b plays a key role in regulating the inflammatory response, acting as a receptor for both tumour necrosis factor alpha (TNF-alpha) and TNF-beta, and is also involved in programmed cell death and anti-viral activity. sTNFRII acts as an inhibitor of TNF-alpha induced responses, by acting as a decoy receptor.
  

Target Info

• Gene Symbol: TNFRSF1B
• Alias Symbols: p75, TBPII, TNFBR, TNFR2, CD120b, TNFR1B, TNFR80, TNF-R75, p75TNFR, TNF-R-II
• NCBI Gene Id: 7133
• Protein Name: Tumor necrosis factor receptor superfamily member 1B
• Description of Target: RECOMBINANT HUMAN CD120b
  
• Uniprot ID: P20333
• Protein Accession #: NP_001057.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 18.9kD (174 amino acid residues)