Catalog No: OPSN00008
Size:100ug
Price: $370.00
SKU
OPSN00008
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Datasheets/ManualsPrintable datasheet for OPSN00008
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. 50 mM Tris-HCL, 1M NaCl, pH 7.5
HostSf9 Baculovirus
ConjugationUnconjugated
ApplicationELISA, IA, AA, FN
Reconstitution and StorageStore at -20C
Formulation50 mM Tris-HCL, 1M NaCl, pH 7.5
PurificationProtein G followed by cleavage of Fc
Concentration0.37 mg/mL
Purity90%
TagNone
DescriptionThe Human ACE2 (Angiotensin-converting Enzyme 2) Recombinant Protein (OPSN00008) (amino acids 19-615) is expressed in Sf9 Baculovirus cells and purified using an Fc tag with Protein A/G chromatography followed by cleavage of the Fc tag. Useful for antibody or Coronavirus Spike interaction assays in a variety of formats.
Gene SymbolACE2
Gene Full Nameangiotensin converting enzyme 2
Alias SymbolsACEH
NCBI Gene Id59272
Protein Nameangiotensin-converting enzyme 2
Description of TargetThe protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.
Swissprot IdQ9BYF1
Protein Size (# AA)AA 19-615
Molecular Weight75kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express ACE2.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express ACE2.
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