Human ACE2 Recombinant Protein (OPSN00008)

Catalog No: OPSN00008

Size:100ug

Purified protein (1 ug) was loaded onto a 4-12% Bis-tris SDS-PAGE gel, electrophoresed and coomassie stained to demonstrate recombinant protein integrity and purity. Gels were imaged with a white background post destain.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. 50 mM Tris-HCL, 1M NaCl, pH 7.5
• Host: Sf9 Baculovirus
• Conjugation: Unconjugated
• Application: ELISA, IA, AA, FN
• Reconstitution and Storage: Store at -20C
• Formulation: 50 mM Tris-HCL, 1M NaCl, pH 7.5
• Purification: Protein G followed by cleavage of Fc
• Concentration: 0.37 mg/mL
• Purity: 90%
• Tag: None
• Description: The Human ACE2 (Angiotensin-converting Enzyme 2) Recombinant Protein (OPSN00008) (amino acids 19-615) is expressed in Sf9 Baculovirus cells and purified using an Fc tag with Protein A/G chromatography followed by cleavage of the Fc tag. Useful for antibody or Coronavirus Spike interaction assays in a variety of formats.

Target Info

• Gene Symbol: ACE2
• Gene Full Name: angiotensin converting enzyme 2
• Alias Symbols: ACEH
• NCBI Gene Id: 59272
• Protein Name: angiotensin-converting enzyme 2
• Description of Target: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.
• Uniprot ID: Q9BYF1
• Protein Size (# AA): AA 19-615
• Molecular Weight: 75kDa