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HTR2B Antibody (C - terminal region E423) (OAAB07368)

  • Catalog#: OAAB07368
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Gene Symbol:
HTR2B
NCBI Gene Id:
3357
Protein Name:
5-hydroxytryptamine receptor 2B
Swissprot Id:
P41595
Protein Accession #:
NP_000858.3
Alias Symbols:
HTR2B, 5-hydroxytryptamine receptor 2B, Serotonin receptor 2B
Description of Target:
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
54298 Da
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB, IHC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express HTR2B.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express HTR2B.
Immunogen:
This HTR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-435 amino acids from the C-terminal region of human HTR2B.
Predicted Species Reactivity:
Mouse
Predicted Homology Based on Immunogen Sequence:
Mouse
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for OAAB07368
Isotype:
Ig
Application Info:
IHC-P: 1:25
WB: 1:2000
WB: 1:1000
Additional Information:
Precautions: HTR2B Antibody (C-term E423) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down- stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
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Cellular Location: Cell membrane; Multi-pass membrane protein.Cell junction, synapse, synaptosome (By similarity)
Tissue Location: Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex
Publications:

Cataldo, LR; Mizgier, ML; Bravo Sagua, R; Jaña, F; Cárdenas, C; Llanos, P; Busso, D; Olmos, P; Galgani, JE; Santos, JL; Cortés, VA; Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells. 12, e0170213 (2017). WB, IHC, Mouse 28129327

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