Size:400ul
$390.00
Discontinued
SKU
OAAB07368
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HTR2B Antibody (C - terminal region E423) (OAAB07368)

Catalog#: OAAB07368
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More Information
Predicted Species Reactivity Mouse
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality Polyclonal
Isotype Ig
Host Rabbit
Application WB, IHC
Additional Information Precautions: HTR2B Antibody (C-term E423) is for research use only and not for use in diagnostic or therapeutic procedures.
:: Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down- stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
:: Cellular Location: Cell membrane; Multi-pass membrane protein.Cell junction, synapse, synaptosome (By similarity)
Tissue Location: Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Immunogen This HTR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-435 amino acids from the C-terminal region of human HTR2B.
Predicted Homology Based on Immunogen Sequence Mouse
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals Printable datasheet for OAAB07368
Application Info IHC-P: 1:25
WB: 1:2000
WB: 1:1000
Publications

Cataldo, LR; Mizgier, ML; Bravo Sagua, R; Jaña, F; Cárdenas, C; Llanos, P; Busso, D; Olmos, P; Galgani, JE; Santos, JL; Cortés, VA; Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells. 12, e0170213 (2017). WB, IHC, Mouse 28129327

Gene Symbol HTR2B
Alias Symbols HTR2B, 5-hydroxytryptamine receptor 2B, Serotonin receptor 2B
NCBI Gene Id 3357
Protein Name 5-hydroxytryptamine receptor 2B
Description of Target Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Swissprot Id P41595
Protein Accession # NP_000858.3
Molecular Weight 54298 Da
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express HTR2B.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express HTR2B.
  1. What is the species homology for "HTR2B Antibody (C - terminal region E423) (OAAB07368)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Mouse".

  2. How long will it take to receive "HTR2B Antibody (C - terminal region E423) (OAAB07368)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "HTR2B Antibody (C - terminal region E423) (OAAB07368)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "HTR2B Antibody (C - terminal region E423) (OAAB07368)"?

    This target may also be called "HTR2B, 5-hydroxytryptamine receptor 2B, Serotonin receptor 2B" in publications.

  5. What is the shipping cost for "HTR2B Antibody (C - terminal region E423) (OAAB07368)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "HTR2B Antibody (C - terminal region E423) (OAAB07368)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "HTR2B Antibody (C - terminal region E423) (OAAB07368)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "54298 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "HTR2B Antibody (C - terminal region E423) (OAAB07368)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "HTR2B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "HTR2B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "HTR2B"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "HTR2B"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "HTR2B"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "HTR2B"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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