HTR2B Antibody (C - terminal region E423) (OAAB07368)

Size:400ul

Mouse Spleen

Human Thyroid

Basic Info

• Predicted Species Reactivity: Mouse
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC
• Additional Information: Precautions: HTR2B Antibody (C-term E423) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down- stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
  Cellular Location: Cell membrane; Multi-pass membrane protein.Cell junction, synapse, synaptosome (By similarity)
  Tissue Location: Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This HTR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-435 amino acids from the C-terminal region of human HTR2B.
• Predicted Homology Based on Immunogen Sequence: Mouse
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Datasheets/Manuals: Printable datasheet for OAAB07368
• Application Info: IHC-P: 1:25
  WB: 1:2000
  WB: 1:1000
• Publications:

  Cataldo, LR; Mizgier, ML; Bravo Sagua, R; Jaña, F; Cárdenas, C; Llanos, P; Busso, D; Olmos, P; Galgani, JE; Santos, JL; Cortés, VA; Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells. 12, e0170213 (2017). WB, IHC, Mouse 28129327

Target Info

• Gene Symbol: HTR2B
• Alias Symbols: HTR2B, 5-hydroxytryptamine receptor 2B, Serotonin receptor 2B
• NCBI Gene Id: 3357
• Protein Name: 5-hydroxytryptamine receptor 2B
• Description of Target: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Swissprot Id: P41595
• Protein Accession #: NP_000858.3
• Molecular Weight: 54298 Da
• Tissue Tool: Find tissues and cell lines supported by DNA array analysis to express HTR2B.
• RNA Seq: Find tissues and cell lines supported by RNA-seq analysis to express HTR2B.