HTR2A Antibody (OAAF02800)

Catalog No: OAAF02800 (Formerly GWB-ASD991)

Size:100 ug

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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-2A Antibody. The picture on the right is treated with the synthesized peptide.

Immunofluorescence analysis of A549 cells, using 5-HT-2A Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human 5-HT-2A.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: 5-HT-2A antibody detects endogenous levels of total 5-HT-2A protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IHC: 1:50~1:100; IF: 1:100~1:500; ELISA: 1:5000
• Reference: Saltzman A.G., Biochem. Biophys. Res. Commun. 181:1469-1478(1991).
  Chen K., Brain Res. Mol. Brain Res. 14:20-26(1992).
  Cook E.H. Jr., J. Neurochem. 63:465-469(1994).

Target Info

• Gene Symbol: HTR2A
• Gene Full Name: 5-hydroxytryptamine receptor 2A
• Alias Symbols: 5-HT2 receptor;5-HT2A;5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled;5-hydroxytryptamine receptor 2A;HTR2;serotonin 5-HT-2A receptor;Serotonin receptor 2A.
• NCBI Gene Id: 3356
• Protein Name: 5-hydroxytryptamine receptor 2A
• Description of Target: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
• Uniprot ID: P28223
• Protein Accession #: NP_000612.1
• Molecular Weight: 52 kDa