HTR1A Antibody - middle region (OAAB18138)

Catalog No: OAAB18138

Size:400ul

Western blot analysis of lysate from human brain tissue lysate, using HTR1A Antibody (Center) (Cat. #OAAB18138).
OAAB18138 was diluted at 1:1000.
A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody.
Lysate at 35ug.
Dilution: 1:1000

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: ICC, IF
  Cellular Location: Cell membrane; Multi-pass membrane protein.
  Tissue Location Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.
  
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This HTR1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 239-273 amino acids from the Central region of human HTR1A.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Intended Use: For research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: FC: 1:25
  WB: 1:1000

Target Info

• Reference: Kobilka B.K., et al.Nature 329:75-79(1987).
  Saltzman A.G., et al.Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases.
  Levy F.O., et al.Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases.
  Kitano T., et al.Mol. Biol. Evol. 21:936-944(2004).
  Puhl H.L. III, et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
• Gene Symbol: HTR1A
• Alias Symbols: G-21, 5HT1a, PFMCD, 5-HT1A, 5-HT-1A, ADRBRL1, ADRB2RL1
• NCBI Gene Id: 3350
• Description of Target: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
• Uniprot ID: P08908
• Molecular Weight: 46 kDa