HSPD1 Antibody - C-terminal region : Biotin (AVARP09014_P050-Biotin)

Catalog No: AVARP09014_P050-Biotin

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Rat, Guinea Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Biotin
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HSPD1
• Predicted Homology Based on Immunogen Sequence: Guinea Pig: 90%; Human: 84%; Rabbit: 84%; Rat: 84%
• Peptide Sequence: Synthetic peptide located within the following region: PTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGG
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-HSPD1 (AVARP09014_P050-Biotin) antibody is Catalog # AAP30181 (Previous Catalog # AAPS08909)
• Reference: Hewamadduma,C.A., (2008) Neurology 70 (19), 1717-1718

Target Info

• Gene Symbol: HSPD1
• Gene Full Name: Heat shock 60kDa protein 1 (chaperonin)
• Alias Symbols: HLD4, CPN60, GROEL, HSP60, HSP65, SPG13, HSP-60, HuCHA60
• NCBI Gene Id: 3329
• Protein Name: 60 kDa heat shock protein, mitochondrial
• Description of Target: HSPD1 is a member of the chaperonin family. This mitochondrial protein may function as a signaling molecule in the innate immune system. It is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Two pseudogenes, both located on chromosome 8, have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.
• Uniprot ID: P10809
• Protein Accession #: NP_002147
• Nucleotide Accession #: NM_002156
• Protein Size (# AA): 573
• Molecular Weight: 61kDa
• Protein Interactions: RGS20; NOTCH2NL; KRTAP10-3; KRTAP10-8; SAMD3; KRT40; LZTS2; CEP70; HUWE1; TMCC2; KRT31; KRTAP5-9; FUS; TUBGCP3; AURKB; VCP; UBC; TUBG1; AURKA; SUMO3; LGALS3BP; CDC20; STAU1; LGR4; NEDD8; MDM2; ERG; ASB4; EED; MAPK14; ATP6V1A; RAB1B; C12orf10; NAGK; C11orf