Size:50 ug
$180.00
In Stock
SKU
OAED00183
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More Information
Predicted Species Reactivity Human, Mouse, Rat
Product Format Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage Long Term Storage : -20C. Avoid freeze/thaw cycles.
Replacement Item This antibody may replace item sc-137210 from Santa Cruz Biotechnology.
Immunogen Synthetic peptide corresponding to the sequence near the C-terminus of human HSC70 (HSP73). The sequence is completely conserved in rat, mouse, bovine, dog, chicken, monkey, and frog.
Purification Protein A affinity purified.
Datasheets/Manuals Printable datasheet for anti-HSPA8 (OAED00183) antibody
Specificity Recognizes human, mouse and rat HSC70 (HSP73). Detects a band of ~73kDa by Western blot.
Application Info Western Blot (1:1000, colorimetric)
Optimal conditions must be determined individually for each application.
Gene Symbol HSPA8
Official Gene Full Name Heat shock cognate 71 kDa protein
NCBI Gene Id 3312
Protein Name Heat shock cognate 71 kDa protein
Description of Target The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1s role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate binding domain of Hsd70 cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.
Swissprot Id P11142
Protein Accession # NP_006588.1; NP_694881.1
Nucleotide Accession # NM_006597.5; NM_153201.3
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express HSPA8.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express HSPA8.
  1. What is the species homology for "HSPA8 Antibody (OAED00183)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "HSPA8 Antibody (OAED00183)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "HSPA8 Antibody (OAED00183)" provided in?

    This item is provided in "Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "HSPA8 Antibody (OAED00183)"?

    This target may also be called "" in publications.

  5. What is the shipping cost for "HSPA8 Antibody (OAED00183)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "HSPA8 Antibody (OAED00183)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "HSPA8 Antibody (OAED00183)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "HSPA8 Antibody (OAED00183)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "HSPA8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "HSPA8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "HSPA8"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "HSPA8"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "HSPA8"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "HSPA8"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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