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More Information
Predicted Species Reactivity Human, Mouse, Rat
Product Format Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage Long Term Storage : -20C. Avoid freeze/thaw cycles.
Replacement Item This antibody may replace item sc-137210 from Santa Cruz Biotechnology.
Immunogen Synthetic peptide corresponding to the sequence near the C-terminus of human HSC70 (HSP73). The sequence is completely conserved in rat, mouse, bovine, dog, chicken, monkey, and frog.
Purification Protein A affinity purified.
Datasheets/Manuals Printable datasheet for anti-HSPA8 (OAED00183) antibody
Specificity Recognizes human, mouse and rat HSC70 (HSP73). Detects a band of ~73kDa by Western blot.
Application Info Western Blot (1:1000, colorimetric)
Optimal conditions must be determined individually for each application.
Gene Symbol HSPA8
Official Gene Full Name Heat shock cognate 71 kDa protein
NCBI Gene Id 3312
Protein Name Heat shock cognate 71 kDa protein
Description of Target The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1s role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate binding domain of Hsd70 cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.
Swissprot Id P11142
Protein Accession # NP_006588.1; NP_694881.1
Nucleotide Accession # NM_006597.5; NM_153201.3
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express HSPA8.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express HSPA8.
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