HSPA8 Antibody (OAED00156)

Catalog No: OAED00156

Size:50 ug

Western blot analysis: Lane 1: MW marker; Lane 2: HSP70B' Recombinant Protein; Lane 3: HeLa Cell Lysate (Heat Shocked).

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Clone: 165f
• Isotype: IgG1
• Host: Mouse
• Application: Western blot
• Reconstitution and Storage: Long Term Storage : -20C
  
• Immunogen: Synthetic peptide corresponding to the sequence near the C-terminus of human HSP70B.
• Specificity: Recognizes human HSP70B. Detects a band of ~70kDa by Western blot.
• Formulation: Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
• Purity: Protein G affinity purified.
  
• Application Info: Western Blot (1:1000, ECL)
  Optimal conditions must be determined individually for each application.

Target Info

• Gene Symbol: HSPA6
• Gene Full Name: heat shock protein family A (Hsp70) member 6
• Alias Symbols: epididymis secretory sperm binding protein;heat shock 70 kDa protein 6;heat shock 70 kDa protein B';heat shock 70kD protein 6 (HSP70B');heat shock 70kDa protein 6 (HSP70B');HSP70B'.
• NCBI Gene Id: 3310
• Protein Name: Heat shock 70 kDa protein 6
• Description of Target: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).
• Uniprot ID: P17066
• Protein Accession #: NP_006588.1; NP_694881.1
• Nucleotide Accession #: NM_006597.5; NM_153201.3