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Catalog No: ARP48445_P050
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ARP48445_P050
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Datasheets/ManualsPrintable datasheet for anti-HSPA8 (ARP48445_P050) antibody
Product Info
Tested Species ReactivityHuman, Mouse, Rat
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Goat, Pig, Sheep, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human HSPA8
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Goat: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
Peptide SequenceSynthetic peptide located within the following region: MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERL
Concentration0.5 mg/ml
Blocking PeptideFor anti-HSPA8 (ARP48445_P050) antibody is Catalog # AAP48445 (Previous Catalog # AAPY01867)
Sample Type Confirmation

HSPA8 is strongly supported by BioGPS gene expression data to be expressed in Jurkat, MCF7

Enhanced Validation
Relative Expression (Western Blot) Avivasheild
ReferenceLuciano,M., (er) Eur. J. Hum. Genet. (2008) In press
Publications

Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess a-Synuclein at Synapses. Eneuro. 7, (2020). 31941659

Description
Gene SymbolHSPA8
Gene Full NameHeat shock 70kDa protein 8
Alias SymbolsLAP1, HSC54, HSC70, HSC71, HSP71, HSP73, LAP-1, NIP71, HEL-33, HSPA10, HEL-S-72p
NCBI Gene Id3312
Protein NameHeat shock cognate 71 kDa protein
Description of TargetHSPA8 belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. HSPA8 is a heat-shock cognate protein. The protein binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date.The product encoded by this gene belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This gene encodes a heat-shock cognate protein. This protein binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date.
Uniprot IDP11142
Protein Accession #NP_006588
Nucleotide Accession #NM_006597
Protein Size (# AA)646
Molecular Weight71kDa
Protein InteractionsFUS; HSPBP1; TRIM38; STUB1; ISG15; UBC; TP53; BAG1; BAG3; IL32; NMI; AIRE; HAUS2; TUBGCP4; CEP250; TUBGCP2; TUBGCP3; TUBG1; AURKA; SUMO2; SUMO3; MDM2; LGALS3BP; CDKN1A; CDC20; HAUS1; STAU1; ST13; HSPA4; HSPA2; DNAJA1; GABRB1; EDRF1; DNAJC9; HSPA4L; HSPH1;
  1. What is the species homology for "HSPA8 Antibody - N-terminal region (ARP48445_P050)"?

    The tested species reactivity for this item is "Human, Mouse, Rat". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Goat, Pig, Sheep, Zebrafish".

  2. How long will it take to receive "HSPA8 Antibody - N-terminal region (ARP48445_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "HSPA8 Antibody - N-terminal region (ARP48445_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "HSPA8 Antibody - N-terminal region (ARP48445_P050)"?

    This target may also be called "LAP1, HSC54, HSC70, HSC71, HSP71, HSP73, LAP-1, NIP71, HEL-33, HSPA10, HEL-S-72p" in publications.

  5. What is the shipping cost for "HSPA8 Antibody - N-terminal region (ARP48445_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "HSPA8 Antibody - N-terminal region (ARP48445_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "HSPA8 Antibody - N-terminal region (ARP48445_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "71kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "HSPA8 Antibody - N-terminal region (ARP48445_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "HSPA8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "HSPA8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "HSPA8"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "HSPA8"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "HSPA8"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "HSPA8"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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