HSP70/HSP72 Antibody (OAED00176)

Catalog No: OAED00176

Size:50 ug

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Bovine, Dog, Chicken, Fish, Teal
• Clonality: Monoclonal
• Clone: C92F3A-5
• Isotype: IgG1
• Host: Mouse
• Application: EIA, WB
• Reconstitution and Storage: Long Term Storage : -20C
  
• Immunogen: Native human Hsp70.
• Specificity: Recognizes human, mouse, rat, bovine, dog, chicken, fish, and teal HSP70 (HSP72).
• Formulation: Liquid. In PBS containing 50% glycerol and 0.03% Thimerosol.
• Purity: Purified.
  
• Application Info: EIA
  Western Blot (1:1000, colorimetric)
  Optimal conditions must be determined individually for each application.
• Reference: Augmentation of immune cell activity against tumor cells by Rauwolfia radix: J.C. Cyong, et al. ; J. Ethnopharmacol. 81, 365 (2002), Application(s): EIA using human samples, Abstract;
  Estramustine phosphate enhances the effects of hyperthermia and induces the small heat shock protein HSP27 in the human prostate carcinoma cell line PC-3: P.L. Moseley, et al. ; Urol. Res. 30, 130 (2002), Application(s): WB using human samples, Abstract;
  Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat: H. Naito, et al. ; J. Appl. Physiol. 91, 2205 (2001), Application(s): WB using rat samples, Abstract;
  Stress protein induction in skeletal muscle comparison of laboratory models to naturally occurring hypertrophy: C.R. Ross, et al. ; J. Appl. Physiol. 76, 598 (1994), Application(s): WB using teal samples, Abstract;
  

Target Info

• Gene Symbol: HSP70/HSP72
• Description of Target: The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
• Uniprot ID: P08107