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HSD17B2 Antibody (OABB00557)

100 ug
$269.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Lyophilized
Clonality:
Polyclonal
Application:
WB, IHC-P
Additional Information:
Content: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
:::
Background: HSD17B2(17-BETA-HYDROXYSTEROID DEHYDROGENASE II), also called 17-BETA-HSD II, is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum. Its Cytogenetic location is 16q23.3. The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42 (43%) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2.And HSD17B2 activity distinguishing between disease-free and diseased endometria. HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.
Reconstitution and Storage:
0.2ml of distilled water will yield a concentration of 500ug/ml. At -20C for one year. After reconstitution, at 4C for one month. It can
also be aliquotted and stored frozen at -20C for a longer time.
Avoid repeated freezing and thawing
Replacement Item:
This antibody may replace item sc-61914 from Santa Cruz Biotechnology.
Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminal of human HSD17B2.
Purification:
Immunogen affinity purified
Predicted Homology Based on Immunogen Sequence:
Human
Datasheets/Manuals:
Printable datasheet for anti-HSD17B2 (OABB00557) antibody
Specificity:
Rabbit IgG
Target Reference:
1. Berube, D., Luu-The, V., Simard, J., Gagne, R., Labrie, F. Localization of the beta-estradiol
dehydrogenase genes to q11-q12 of chromosome 17. (Abstract) Cytogenet. Cell Genet. 51: 962
only, 1989.
2. Geissler, W. M., Davis, D. L., Wu, L., Bradshaw, K. D., Patel, S., Mendonca, B. B., Elliston, K. O.,
Wilson, J. D., Russell, D. W., Andersson, S. Male pseudohermaphroditism caused by mutations of
testicular 17-beta-hydroxysteroid dehydrogenase
3. Nature Genet. 7: 34-39, 1994. 3. Harkness, R. A., Thistlethwaite, D., Darling, J. A. B., Skakkebaek,
N. E., Corker, C. S. Neutral 17-beta-hydroxysteroid oxidoreductase deficiency in testes causing
male pseudohermaphroditism in an infant. J. Inherit. Metab. Dis. 2: 51-54, 1979
Gene Symbol:
HSD17B2
Official Gene Full Name:
Estradiol 17-beta-dehydrogenase 2
NCBI Gene Id:
3294
Protein Name:
Estradiol 17-beta-dehydrogenase 2
Swissprot Id:
P37059
Protein Accession #:
NP_002144.1
Nucleotide Accession #:
NM_002153.2
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express HSD17B2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express HSD17B2.

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