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Catalog No: OPCD03991
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OPCD03991
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Datasheets/ManualsPrintable datasheet for HSD17B12 Recombinant Protein (OPCD03991)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Met1-Asn312
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 97%
SourceE.coli
TagN-terminal His Tag
Gene SymbolHSD17B12
Gene Full Namehydroxysteroid 17-beta dehydrogenase 12
Alias Symbols17-beta-HSD 12;17beta-HSD type 12;17-beta-hydroxysteroid dehydrogenase 12;3-ketoacyl-CoA reductase;estradiol 17-beta-dehydrogenase 12;KAR;SDR12C1;short chain dehydrogenase/reductase family 12C member 1;steroid dehydrogenase homolog;very-long-chain 3-oxoacyl-CoA reductase.
NCBI Gene Id51144
Protein NameVery-long-chain 3-oxoacyl-CoA reductase
Description of TargetCatalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Uniprot IDQ53GQ0
Protein Accession #NP_057226.1
Nucleotide Accession #NM_016142.2
Protein Size (# AA)Met1~Asn312
Molecular Weight38kDa
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