Catalog No: ARP45714_P050-HRP
Size:100ul
Price: $434.00
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ARP45714_P050-HRP
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HSD11B1 Antibody - N-terminal region : HRP (ARP45714_P050-HRP)

Datasheets/ManualsPrintable datasheet for anti-HSD11B1 (ARP45714_P050-HRP) antibody
Product Info
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep
Product FormatLiquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
ClonalityPolyclonal
HostRabbit
ConjugationHRP: Horseradish Peroxidase
ApplicationIHC, WB
Additional InformationIHC Information: Western analysis of fetal liver lysate.
Reconstitution and StorageAll conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human HSD11B1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Sheep: 93%
Peptide SequenceSynthetic peptide located within the following region: QKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHI
Concentration0.5 mg/ml
Blocking PeptideFor anti-HSD11B1 (ARP45714_P050-HRP) antibody is Catalog # AAP45714 (Previous Catalog # AAPP11847)
ReferencePaulsen,S.K., (2008) Obesity (Silver Spring) 16 (4), 731-735
Publications

Lei, K. et al. Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1β-induced COX-2 expression in human term myometrial cells. PLoS One 7, e50167 (2012). WB, IHC, Mouse, Rat, Guinea pig, Human, Horse, Rabbit, Dog, Sheep, Bovine 23209664

Kuroda, K. et al. Induction of 11β-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Mol. Endocrinol. 27, 192-202 (2013). WB, IHC, Mouse, Rat, Guinea pig, Human, Horse, Rabbit, Dog, Sheep, Bovine 23275455

Gene SymbolHSD11B1
Gene Full NameHydroxysteroid (11-beta) dehydrogenase 1
Alias SymbolsHDL, 11-DH, HSD11, HSD11B, HSD11L, CORTRD2, SDR26C1, 11-beta-HSD1
NCBI Gene Id3290
Protein NameCorticosteroid 11-beta-dehydrogenase isozyme 1
Description of TargetHSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
Uniprot IDP28845
Protein Accession #NP_005516
Nucleotide Accession #NM_005525
Protein Size (# AA)292
Molecular Weight32kDa
Protein InteractionsGKAP1; CD36;
  1. What is the species homology for "HSD11B1 Antibody - N-terminal region : HRP (ARP45714_P050-HRP)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep".

  2. How long will it take to receive "HSD11B1 Antibody - N-terminal region : HRP (ARP45714_P050-HRP)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "HSD11B1 Antibody - N-terminal region : HRP (ARP45714_P050-HRP)" provided in?

    This item is provided in "Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "HSD11B1 Antibody - N-terminal region : HRP (ARP45714_P050-HRP)"?

    This target may also be called "HDL, 11-DH, HSD11, HSD11B, HSD11L, CORTRD2, SDR26C1, 11-beta-HSD1" in publications.

  5. What is the shipping cost for "HSD11B1 Antibody - N-terminal region : HRP (ARP45714_P050-HRP)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "HSD11B1 Antibody - N-terminal region : HRP (ARP45714_P050-HRP)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "HSD11B1 Antibody - N-terminal region : HRP (ARP45714_P050-HRP)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "32kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "HSD11B1 Antibody - N-terminal region : HRP (ARP45714_P050-HRP)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "HSD11B1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "HSD11B1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "HSD11B1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "HSD11B1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "HSD11B1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "HSD11B1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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