HRAS Antibody - C-terminal region (ARP74951_P050)

Catalog No: ARP74951_P050

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Host: Rabbit
Target Name: RASH
Sample Type: U937 Whole Cell lysates
Antibody Dilution: 1.0ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human RASH
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: QDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-HRAS (ARP74951_P050) antibody is Catalog # AAP74951
• Reference: N/A

Target Info

• Gene Symbol: HRAS
• Gene Full Name: HRas proto-oncogene, GTPase
• Alias Symbols: CTLO, HAMSV, HRAS1, RASH1, p21ras, C-H-RAS, H-RASIDX, C-BAS/HAS, C-HA-RAS1
• NCBI Gene Id: 3265
• Protein Name: GTPase HRas
• Description of Target: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
• Uniprot ID: P01112
• Protein Size (# AA): 189
• Molecular Weight: 20kDa
• Protein Interactions: RIN1; LGALS1; ABL2; DAB2IP; RASSF5; RAF1; KRT18; SLC9A3R2; TPR; PSMB2; NEDD8; ZHX2; LATS2; PPP1R13B; TP53; RNF115; BRAP; CBL; SPRY2; UBC; SH3KBP1; RABGEF1; BTRC; DEAF1; RGL1; RALGDS; RGL2; GRIN1; ZBTB12; RIT2; RASSF2; RASIP1; TTC1; RAP1GDS1; RGL4; RASGRP4