HPD Antibody - C-terminal region (OAAB05184)

Catalog No: OAAB05184

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Western blot analysis of HPD Antibody (C-term) in mouse liver tissue lysates (35ug/lane). HPD (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with HPD Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Mouse
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC-P
• Additional Information: Function: Key enzyme in the degradation of tyrosine.
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This HPD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-284 amino acids from the C-terminal region of human HPD.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: 0.5 mg/ml
• Intended Use: For research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:1000
  IHC-P: 1:50~100
  Optimal dilutions should be determined by the end user.
• Reference: Item,C.B., et.al., Mol. Genet. Metab. 91 (4), 379-383 (2007)
  Wistow,G., et.al., Mol. Vis. 8, 171-184 (2002)

Target Info

• Gene Symbol: HPD
• Alias Symbols: PPD, 4HPPD, GLOD3, 4-HPPD, HPPDASE
• NCBI Gene Id: 3242
• Protein Name: 4-hydroxyphenylpyruvate dioxygenase
• Description of Target: HPD is an enzyme in the catabolic pathway of tyrosine. This protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate.
• Uniprot ID: P32754
• Protein Accession #: NP_001165464.1
• Molecular Weight: 45 kDa