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HNRPD Antibody - C-terminal region (ARP40238_T100)

100 ul
$229.00
In Stock
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Conjugation Options

ARP40238_T100-FITC Conjugated

ARP40238_T100-HRP Conjugated

ARP40238_T100-Biotin Conjugated

Gene Symbol:
HNRNPD
Official Gene Full Name:
Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
NCBI Gene Id:
3184
Protein Name:
Heterogeneous nuclear ribonucleoprotein D0
Swissprot Id:
Q14103
Protein Accession #:
NP_112738
Nucleotide Accession #:
NM_031370
Alias Symbols:
P37, AUF1, AUF1A, HNRPD, hnRNPD0
Replacement Item:
This antibody may replace item sc-166577 from Santa Cruz Biotechnology.
Description of Target:
HNRPD belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
Protein Size (# AA):
355
Molecular Weight:
39kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express HNRPD.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express HNRPD.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human HNRPD
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 79%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Complete computational species homology data:
Anti-HNRPD (ARP40238_T100)
Peptide Sequence:
Synthetic peptide located within the following region: YGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSRRGGHQNSYKP
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
NCL; FUS; KAT2B; SUMO2; SUMO3; IVNS1ABP; STAU1; UBC; NEDD8; MDM2; ERG; RPA3; RPA2; RPA1; ASB2; EED; rev; ERI1; RPS12; PTBP1; PAFAH1B3; WNK1; IPO11; EIF3K; KHSRP; DENR; PARK2; DGCR2; GTF3C3; PDLIM7; UQCRC1; HIRA; SNAPC4; SLC3A2; SDF2; COG7; TMEM261; ABCC10
Blocking Peptide:
For anti-HNRNPD (ARP40238_T100) antibody is Catalog # AAP40238 (Previous Catalog # AAPP22082)
Datasheets/Manuals:
Printable datasheet for anti-HNRNPD (ARP40238_T100) antibody
Sample Type Confirmation:

HNRNPD is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Target Reference:
Dhakras,P.S., Am. J. Physiol. Renal Physiol. 290 (2), F313-F318 (2006)
Publications:

Kang, X., Chen, W., Kim, R. H., Kang, M. K. & Park, N.-H. Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells. Oncogene 28, 565-74 (2009). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish 19015635

Subramaniam, K., Ooi, L. L. P. J. & Hui, K. M. Transcriptional down-regulation of IGFBP-3 in human hepatocellular carcinoma cells is mediated by the binding of TIA-1 to its AT-rich element in the 3’-untranslated region. Cancer Lett. 297, 259-68 (2010). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish 20599318

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