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HNRPAB Antibody - C-terminal region (ARP41036_T100)

100 ul
$229.00
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Conjugation Options

ARP41036_T100-FITC Conjugated

ARP41036_T100-HRP Conjugated

ARP41036_T100-Biotin Conjugated

Gene Symbol:
HNRNPAB
Official Gene Full Name:
Heterogeneous nuclear ribonucleoprotein A/B
NCBI Gene Id:
3182
Protein Name:
Heterogeneous nuclear ribonucleoprotein A/B
Swissprot Id:
Q99729-2
Protein Accession #:
NP_112556
Nucleotide Accession #:
NM_031266
Alias Symbols:
ABBP1, HNRPAB
Replacement Item:
This antibody may replace item sc-15385 from Santa Cruz Biotechnology.
Description of Target:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Protein Size (# AA):
332
Molecular Weight:
37kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express HNRPAB.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express HNRPAB.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human HNRPAB
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 93%; Zebrafish: 93%
Complete computational species homology data:
Anti-HNRPAB (ARP41036_T100)
Peptide Sequence:
Synthetic peptide located within the following region: QQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; SUMO2; IVNS1ABP; STAU1; DROSHA; MDM2; LIN28A; RPA3; RPA2; RPA1; ERG; RNF2; EZH2; EED; rev; YBX1; LDHB; TARDBP; HMGA1; USP19; PAN2; PTBP2; TP63; UBL4A; WHSC1; PTBP1; ITGA4; IL7R; IFIT3; IFIT2; FN1; SMURF1; ESR1; HNRNPA2B1; ATP6AP1; MRPS25; MRPS7; MRPS
Blocking Peptide:
For anti-HNRNPAB (ARP41036_T100) antibody is Catalog # AAP41036 (Previous Catalog # AAPS02301)
Datasheets/Manuals:
Printable datasheet for anti-HNRNPAB (ARP41036_T100) antibody
Sample Type Confirmation:

HNRNPAB is supported by BioGPS gene expression data to be expressed in Daudi

Target Reference:
Gao,C., (2004) J. Biol. Chem. 279 (12), 11236-11243
Publications:

Bubenik, J. L., Ladd, A. N., Gerber, C. A., Budiman, M. E. & Driscoll, D. M. Known turnover and translation regulatory RNA-binding proteins interact with the 3’ UTR of SECIS-binding protein 2. RNA Biol. 6, 73-83 (2009). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish 19106619

Taga, Y., Miyoshi, M., Okajima, T., Matsuda, T. & Nadano, D. Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland. Cell Biochem. Funct. 28, 321-8 (2010). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish 20517897

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