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Catalog No: OPPA02223 (Formerly GWB-545412)
Size:10UG
Price: $75.00
SKU
OPPA02223
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HMOX1 Protein (OPPA02223)

Datasheets/ManualsPrintable datasheet for OPPA02223
Product Info
Predicted Species ReactivityHuman
Product FormatHMOX1 solution containing 20mM Tris pH-8, 50mM NaCl, 0.1mM PMSF and 10% glycerol. Physical appearance: Sterile filtered colorless solution.
HostE. Coli
::Product Introduction: HMOX1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is then converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HMOX1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme Oxygenase-1 is involved in the regulation of cardiovascular function and its adaptive response to a variety of stressors. HMOX1 is induced in the colon of ulcerative colitis. HMOX1 is found to overexpress with a higher extent of intraplaque angiogenesis implies a multi-faceted role for HMOX1 in modulating the progression of atherosclerosis. HMOX1 expression reduced LPS-stimulated secretion of MCP-1, IL-6, IL-10, and TNF-alpha in murine and human macrophages.
Product Description: HO-1 Human Recombinant protein produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 274 amino acids (1-266) and having a molecular mass of 31.4 kDa. HO-1 is fused to 8 amino acid His Tag at C-Terminus and purified by proprietary chromatographic techniques.
Reconstitution and StorageHMOX1 Human Recombinant although stable at 4C for 1 week, should be stored desiccated below -18C. Please prevent freeze thaw cycles.
PurityGreater than 95.0% as determined by SDS-PAGE.
Peptide SequenceMERPQPHSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALEQDLAFWYGPR WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQLYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV ETPRGKPPLN TRSQAPLEHHHHHH.
Gene SymbolHMOX1
Alias SymbolsHO-1, HSP32, HMOX1D, bK286B10
NCBI Gene Id3162
Protein NameHeme oxygenase 1
Description of TargetRecombinant Human Heme Oxygenase 1
Uniprot IDP09601
Protein Accession #NP_002124.1
Protein Size (# AA)Recombinant
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