Size:100 ul
Special Price $229.00 Regular Price $289.00
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ARP38532_P050
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Conjugation Options

ARP38532_P050-FITC Conjugated

ARP38532_P050-HRP Conjugated

ARP38532_P050-Biotin Conjugated

HMGN1 Antibody - middle region (ARP38532_P050)

Catalog#: ARP38532_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species ReactivityHuman
Predicted Species ReactivityCow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement ItemThis antibody may replace item sc-19074 from Santa Cruz Biotechnology.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human HMGN1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 93%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 79%; Pig: 100%; Rabbit: 93%; Rat: 79%
Complete computational species homology dataAnti-HMGN1 (ARP38532_P050)
Peptide SequenceSynthetic peptide located within the following region: QTKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEAKSD
ConcentrationBatch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking PeptideFor anti-HMGN1 (ARP38532_P050) antibody is Catalog # AAP38532 (Previous Catalog # AAPP20723)
Datasheets/ManualsPrintable datasheet for anti-HMGN1 (ARP38532_P050) antibody
Target ReferenceZhu,N. (2007) Mol. Cell. Biol. 27 (24), 8859-8873
Publications

Lane, A. A. et al. Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nat. Genet. 46, 618-23 (2014). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat 24747640

Gene SymbolHMGN1
Official Gene Full NameHigh mobility group nucleosome binding domain 1
Alias SymbolsFLJ27265, FLJ31471, HMG14, MGC104230, MGC117425
NCBI Gene Id3150
Protein NameHigh-mobility group nucleosome binding domain 1 EMBL AAH70154.1
Description of TargetChromosomal protein HMG14 (HMGN1) and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot IdQ6NSG7
Protein Accession #NP_004956
Nucleotide Accession #NM_004965
Protein Size (# AA)100
Molecular Weight11kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express HMGN1.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express HMGN1.
Protein InteractionsUBC; RPS6KA3; PRKCA; PRKACG; SLC38A3; PPP1CC; LIG4; PPIP5K1; TERF2; SPP1; POLR2A; ERCC8; HDGF; EP300; BTG2; ERCC6; NFE2; RPS6KA5; RPS6KA4; PRKACA; YWHAZ; HMGN1; HMGN2; IRF2;
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