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HMGN1 Antibody - middle region (ARP38532_P050)

100 ul
$289.00
In Stock
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Conjugation Options

ARP38532_P050-FITC Conjugated

ARP38532_P050-HRP Conjugated

ARP38532_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
HMGN1
Official Gene Full Name:
High mobility group nucleosome binding domain 1
NCBI Gene Id:
3150
Protein Name:
High-mobility group nucleosome binding domain 1 EMBL AAH70154.1
Swissprot Id:
Q6NSG7
Protein Accession #:
NP_004956
Nucleotide Accession #:
NM_004965
Alias Symbols:
FLJ27265, FLJ31471, HMG14, MGC104230, MGC117425
Replacement Item:
This antibody may replace item sc-19074 from Santa Cruz Biotechnology.
Description of Target:
Chromosomal protein HMG14 (HMGN1) and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
100
Molecular Weight:
11kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express HMGN1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express HMGN1.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human HMGN1
Predicted Homology Based on Immunogen Sequence:
Cow: 93%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 79%; Pig: 100%; Rabbit: 93%; Rat: 79%
Complete computational species homology data:
Anti-HMGN1 (ARP38532_P050)
Peptide Sequence:
Synthetic peptide located within the following region: QTKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEAKSD
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; RPS6KA3; PRKCA; PRKACG; SLC38A3; PPP1CC; LIG4; PPIP5K1; TERF2; SPP1; POLR2A; ERCC8; HDGF; EP300; BTG2; ERCC6; NFE2; RPS6KA5; RPS6KA4; PRKACA; YWHAZ; HMGN1; HMGN2; IRF2;
Blocking Peptide:
For anti-HMGN1 (ARP38532_P050) antibody is Catalog # AAP38532 (Previous Catalog # AAPP20723)
Datasheets/Manuals:
Printable datasheet for anti-HMGN1 (ARP38532_P050) antibody
Target Reference:
Zhu,N. (2007) Mol. Cell. Biol. 27 (24), 8859-8873
Publications:

Lane, A. A. et al. Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nat. Genet. 46, 618-23 (2014). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat 24747640

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