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| Datasheets/Manuals | Printable datasheet for anti-HMGCR (ARP97712_P050) antibody |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the C terminal region of human HMGCR |
| Purification | Affinity purified |
| Peptide Sequence | Synthetic peptide located within the following region: GTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAAL |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-HMGCR (ARP97712_P050) antibody is Catalog # AAP97712 |
| Gene Symbol | HMGCR |
|---|---|
| Gene Full Name | 3-hydroxy-3-methylglutaryl-CoA reductase |
| Alias Symbols | LDLCQ3 |
| NCBI Gene Id | 3156 |
| Protein Name | LDLCQ3 |
| Description of Target | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | P04035 |
| Protein Accession # | NP_000850.1 |
| Nucleotide Accession # | NM_000859.2 |
| Protein Size (# AA) | 888 |
| Molecular Weight | 97 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "HMGCR Antibody - C-terminal region (ARP97712_P050)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".
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How long will it take to receive "HMGCR Antibody - C-terminal region (ARP97712_P050)"?
This item is available "Domestic: within 24 hours delivery | International: 3-5 days".
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What buffer format is "HMGCR Antibody - C-terminal region (ARP97712_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "HMGCR Antibody - C-terminal region (ARP97712_P050)"?
This target may also be called "LDLCQ3" in publications.
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What is the shipping cost for "HMGCR Antibody - C-terminal region (ARP97712_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "HMGCR Antibody - C-terminal region (ARP97712_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "HMGCR Antibody - C-terminal region (ARP97712_P050)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "97 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "HMGCR Antibody - C-terminal region (ARP97712_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "HMGCR"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "HMGCR"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "HMGCR"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "HMGCR"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "HMGCR"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "HMGCR"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.